Fetal growth does not modify the relationship of infant weight gain with childhood adiposity and blood pressure in the Southampton women's survey.
Ann Hum Biol
; 47(2): 150-158, 2020 Mar.
Article
en En
| MEDLINE
| ID: mdl-32429761
ABSTRACT
Background:
Rapid infant weight gain is a risk factor for childhood obesity. This relationship may depend on whether infant weight gain is preceded by in-utero growth restriction.Aim:
Examine whether fetal growth modifies the relationship between infant weight gain and childhood adiposity and blood pressure.Subjects andmethods:
786 children in the Southampton Women's Survey. We related infant weight gain (weight at 2 years-birth weight) to body mass index (BMI), %body fat, trunk fat (kg), systolic (SBP) and diastolic blood pressure (DBP) at age 6-7 years. Mean estimated fetal weight (EFW) between 19-34 weeks and change in EFW (19-34 weeks) were added to models as effect modifiers.Results:
Infant weight gain was positively associated with all childhood outcomes. We found no evidence that these effects were modified by fetal growth (p > .1 for all interaction terms). For example, a 1 standard deviation (SD) increase in infant weight gain was associated with an increase in BMI z-score of 0.51 (95% CI 0.37;0.64) when EFW-change was set at -2 SD-scores compared with an increase of 0.41 (95% CI 0.27;0.54, p(interaction)=.48) when set at 2 SD-scores.Conclusion:
The documented adverse consequences of rapid infant weight gain may occur regardless of whether growth was constrained in-utero.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Presión Sanguínea
/
Aumento de Peso
/
Desarrollo Fetal
/
Adiposidad
/
Obesidad Infantil
Límite:
Humans
/
Infant
/
Newborn
País/Región como asunto:
Europa
Idioma:
En
Revista:
Ann Hum Biol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Reino Unido