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High levels of resistance to nucleoside/nucleotide reverse transcriptase inhibitors in newly diagnosed antiretroviral treatment-naive children in sub-Saharan Africa.
Inzaule, Seth C; Jordan, Michael R; Bello, George; Wadonda-Kabondo, Nellie; Mounerou, Salou; Mbulli, Innocent A; Akanmu, Sulaimon A; Vubil, Adolfo; Hunt, Gillian; Kaleebu, Pontiano; Mthethwa-Hleza, Simangele; Dzangare, Janet; Njukeng, Patrick; Penazzato, Martina; Rinke de Wit, Tobias F; Eshleman, Susan H; Bertagnolio, Silvia.
Afiliación
  • Inzaule SC; HIV/Hepatitis/STI Department, World Health Organization, Geneva, Switzerland.
  • Jordan MR; Tufts University School of Medicine, Boston, USA.
  • Bello G; Ministry of Health, Lilingwe, Malawi.
  • Wadonda-Kabondo N; Centers for Disease Control & Prevention, Lilongwe, Malawi.
  • Mounerou S; Faculty of Health Sciences, Molecular Biology Laboratory, University of Lomé, Lomé, Togo.
  • Mbulli IA; Global Health Systems Solutions, Douala, Cameroon.
  • Akanmu SA; Department of Haematology and Blood Transfusion, Lagos University Teaching Hospital, and College of Medicine of the University of Lagos, Lagos, Nigeria.
  • Vubil A; Instituto Nacional de Saúde, Maputo, Mozambique.
  • Hunt G; National Institute for Communicable Diseases, Johannesburg, South Africa.
  • Kaleebu P; Uganda Virus Research Institute, Entebbe, Uganda.
  • Mthethwa-Hleza S; Ministry of Health Eswatini, Mbabane, Eswatini.
  • Dzangare J; Ministry of Health and Child Care, Harare, Zimbabwe.
  • Njukeng P; Global Health Systems Solutions, Douala, Cameroon.
  • Penazzato M; HIV/Hepatitis/STI Department, World Health Organization, Geneva, Switzerland.
  • Rinke de Wit TF; Amsterdam Institute for Global Health and Development, and Department of Global Health, Amsterdam UMC, University of Amsterdam, The Netherlands.
  • Eshleman SH; Johns Hopkins University. School of Medicine, Baltimore, Maryland, USA.
  • Bertagnolio S; HIV/Hepatitis/STI Department, World Health Organization, Geneva, Switzerland.
AIDS ; 34(10): 1567-1570, 2020 08 01.
Article en En | MEDLINE | ID: mdl-32443062
: Exposure of infants to antiretroviral drugs for prevention of mother-to-child transmission can induce resistance to nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs). Data from nine national surveys of pretreatment drug resistance in children newly diagnosed with HIV show high levels of resistance to NRTIs included in first-line antiretroviral treatment (ART) regimens (dual abacavir-lamivudine/emtricitabine resistance). Additional research is needed to determine the impact of NRTI resistance on treatment response and optimize infant ART.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Infecciones por VIH / Transmisión Vertical de Enfermedad Infecciosa / Inhibidores de la Transcriptasa Inversa / Fármacos Anti-VIH / Farmacorresistencia Viral Tipo de estudio: Diagnostic_studies Límite: Female / Humans / Infant País/Región como asunto: Africa Idioma: En Revista: AIDS Asunto de la revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2020 Tipo del documento: Article País de afiliación: Suiza
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Infecciones por VIH / Transmisión Vertical de Enfermedad Infecciosa / Inhibidores de la Transcriptasa Inversa / Fármacos Anti-VIH / Farmacorresistencia Viral Tipo de estudio: Diagnostic_studies Límite: Female / Humans / Infant País/Región como asunto: Africa Idioma: En Revista: AIDS Asunto de la revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2020 Tipo del documento: Article País de afiliación: Suiza