The Evolving Spectrum of Precursor Lesions of Cervical Adenocarcinomas.
Adv Anat Pathol
; 27(5): 278-293, 2020 Sep.
Article
en En
| MEDLINE
| ID: mdl-32482967
Modern classification schemes divide cervical adenocarcinomas into human papillomavirus (HPV)-associated and HPV-independent types. The precursor lesions of the former are well known and comprise HPV-associated (usual/endocervical) adenocarcinoma in situ (AIS) and the much less common stratified mucin-producing intraepithelial lesion (SMILE). The precursor lesions of HPV-independent cervical adenocarcinomas are much less well known, although postulated precursors of gastric-type adenocarcinoma include atypical lobular endocervical glandular hyperplasia and gastric-type AIS. In this review, we cover HPV-associated and HPV-independent precursor lesions of cervical adenocarcinomas concentrating on diagnostic criteria (morphology and immunophenotype) and differential diagnosis. We propose a uniform terminology and diagnostic criteria for precursor lesions showing intestinal differentiation with goblet cells because this may be a feature of both HPV-associated and HPV-independent AIS.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Adenocarcinoma
/
Neoplasias del Cuello Uterino
/
Cuello del Útero
Límite:
Female
/
Humans
Idioma:
En
Revista:
Adv Anat Pathol
Asunto de la revista:
ANATOMIA
/
PATOLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Rumanía