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Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions.
Mathew, Divij; Giles, Josephine R; Baxter, Amy E; Greenplate, Allison R; Wu, Jennifer E; Alanio, Cécile; Oldridge, Derek A; Kuri-Cervantes, Leticia; Pampena, M Betina; D'Andrea, Kurt; Manne, Sasikanth; Chen, Zeyu; Huang, Yinghui Jane; Reilly, John P; Weisman, Ariel R; Ittner, Caroline A G; Kuthuru, Oliva; Dougherty, Jeanette; Nzingha, Kito; Han, Nicholas; Kim, Justin; Pattekar, Ajinkya; Goodwin, Eileen C; Anderson, Elizabeth M; Weirick, Madison E; Gouma, Sigrid; Arevalo, Claudia P; Bolton, Marcus J; Chen, Fang; Lacey, Simon F; Hensley, Scott E; Apostolidis, Sokratis; Huang, Alexander C; Vella, Laura A; Betts, Michael R; Meyer, Nuala J; Wherry, E John.
Afiliación
  • Mathew D; Institute for Immunology, University of Pennsylvania Perelman School of Medicine.
  • Giles JR; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine.
  • Baxter AE; Institute for Immunology, University of Pennsylvania Perelman School of Medicine.
  • Greenplate AR; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine.
  • Wu JE; Parker Institute for Cancer Immunotherapy at University of Pennsylvania Perelman School of Medicine.
  • Alanio C; Institute for Immunology, University of Pennsylvania Perelman School of Medicine.
  • Oldridge DA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine.
  • Kuri-Cervantes L; Institute for Immunology, University of Pennsylvania Perelman School of Medicine.
  • Pampena MB; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine.
  • D'Andrea K; Institute for Immunology, University of Pennsylvania Perelman School of Medicine.
  • Manne S; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine.
  • Chen Z; Parker Institute for Cancer Immunotherapy at University of Pennsylvania Perelman School of Medicine.
  • Huang YJ; Institute for Immunology, University of Pennsylvania Perelman School of Medicine.
  • Reilly JP; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine.
  • Weisman AR; Parker Institute for Cancer Immunotherapy at University of Pennsylvania Perelman School of Medicine.
  • Ittner CAG; Institute for Immunology, University of Pennsylvania Perelman School of Medicine.
  • Kuthuru O; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine.
  • Dougherty J; Institute for Immunology, University of Pennsylvania Perelman School of Medicine.
  • Nzingha K; Department of Microbiology, University of Pennsylvania Perelman School of Medicine.
  • Han N; Institute for Immunology, University of Pennsylvania Perelman School of Medicine.
  • Kim J; Department of Microbiology, University of Pennsylvania Perelman School of Medicine.
  • Pattekar A; Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania.
  • Goodwin EC; Institute for Immunology, University of Pennsylvania Perelman School of Medicine.
  • Anderson EM; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine.
  • Weirick ME; Institute for Immunology, University of Pennsylvania Perelman School of Medicine.
  • Gouma S; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine.
  • Arevalo CP; Institute for Immunology, University of Pennsylvania Perelman School of Medicine.
  • Bolton MJ; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine.
  • Chen F; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine.
  • Lacey SF; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine.
  • Hensley SE; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine.
  • Apostolidis S; Institute for Immunology, University of Pennsylvania Perelman School of Medicine.
  • Huang AC; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine.
  • Vella LA; Institute for Immunology, University of Pennsylvania Perelman School of Medicine.
  • Betts MR; Institute for Immunology, University of Pennsylvania Perelman School of Medicine.
  • Meyer NJ; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine.
  • Wherry EJ; Institute for Immunology, University of Pennsylvania Perelman School of Medicine.
bioRxiv ; 2020 May 23.
Article en En | MEDLINE | ID: mdl-32511371
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Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: BioRxiv Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: BioRxiv Año: 2020 Tipo del documento: Article