Chrysosplenol d, a Flavonol from <i>Artemisia annua</i>, Induces ERK1/2-Mediated Apoptosis in Triple Negative Human Breast Cancer Cells.

Lang, Sophia J; Schmiech, Michael; Hafner, Susanne; Paetz, Christian; Werner, Katharina; El Gaafary, Menna; Schmidt, Christoph Q; Syrovets, Tatiana; Simmet, Thomas

Chrysosplenol d, a Flavonol from Artemisia annua, Induces ERK1/2-Mediated Apoptosis in Triple Negative Human Breast Cancer Cells.

Lang, Sophia J; Schmiech, Michael; Hafner, Susanne; Paetz, Christian; Werner, Katharina; El Gaafary, Menna; Schmidt, Christoph Q; Syrovets, Tatiana; Simmet, Thomas.

Afiliación

Lang SJ; Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, 89081 Ulm, Germany.
Schmiech M; Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, 89081 Ulm, Germany.
Hafner S; Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, 89081 Ulm, Germany.
Paetz C; Research Group Biosynthesis/Nuclear Magnetic Resonance, Max Planck Institute for Chemical Ecology, 07745 Jena, Germany.
Werner K; Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, 89081 Ulm, Germany.
El Gaafary M; Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, 89081 Ulm, Germany.
Schmidt CQ; Department of Pharmacognosy, College of Pharmacy, Cairo University, Cairo 11562, Egypt.
Syrovets T; Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, 89081 Ulm, Germany.
Simmet T; Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, 89081 Ulm, Germany.

Int J Mol Sci ; 21(11)2020 Jun 08.

Article en En | MEDLINE | ID: mdl-32521698

Asunto(s)

Antineoplásicos Fitogénicos/farmacología; Apoptosis/efectos de los fármacos; Artemisia annua/química; Flavonas/farmacología; Sistema de Señalización de MAP Quinasas/efectos de los fármacos; Animales; Antineoplásicos Fitogénicos/química; Línea Celular Tumoral; Permeabilidad de la Membrana Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Modelos Animales de Enfermedad; Femenino; Flavonas/química; Flavonoides/química; Flavonoides/farmacología; Flavonoles/química; Flavonoles/farmacología; Humanos; Ratones; Mitocondrias/efectos de los fármacos; Mitocondrias/metabolismo; Neoplasias de la Mama Triple Negativas; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

apoptosis; artemisia annua; casticin; cell cycle; chick chorioallantoic membrane assay; chrysosplenol d; methoxylated flavonoids; mitogen-activated protein kinase; triple negative breast cancer

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Apoptosis / Sistema de Señalización de MAP Quinasas / Artemisia annua / Flavonas / Antineoplásicos Fitogénicos Límite: Animals / Female / Humans Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Alemania

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