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Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles.
Wang, Bi; Van Herck, Simon; Chen, Yong; Bai, Xiangyang; Zhong, Zifu; Deswarte, Kim; Lambrecht, Bart N; Sanders, Niek N; Lienenklaus, Stefan; Scheeren, Hans W; David, Sunil A; Kiessling, Fabian; Lammers, Twan; De Geest, Bruno G; Shi, Yang.
Afiliación
  • Wang B; Institute for Experimental Molecular Imaging, Uniklinik RWTH Aachen and Helmholtz Institute for Biomedical Engineering, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
  • Van Herck S; Department of Pharmaceutics, Ghent University, Ghent 9000, Belgium.
  • Chen Y; Department of Pharmaceutics, Ghent University, Ghent 9000, Belgium.
  • Bai X; Institute for Experimental Molecular Imaging, Uniklinik RWTH Aachen and Helmholtz Institute for Biomedical Engineering, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
  • Zhong Z; Laboratory of Gene Therapy, Ghent University, Ghent 9820, Belgium.
  • Deswarte K; Department of Internal Medicine and Pediatrics, Ghent University, VIB Center for Inflammation Research, Ghent, Belgium.
  • Lambrecht BN; Department of Internal Medicine and Pediatrics, Ghent University, VIB Center for Inflammation Research, Ghent, Belgium.
  • Sanders NN; Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam 3015, The Netherlands.
  • Lienenklaus S; Laboratory of Gene Therapy, Ghent University, Ghent 9820, Belgium.
  • Scheeren HW; Institute for Laboratory Animal Science and Institute of Immunology, Hannover Medical School, Hannover 30625, Germany.
  • David SA; Institute for Experimental Molecular Imaging, Uniklinik RWTH Aachen and Helmholtz Institute for Biomedical Engineering, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
  • Kiessling F; Virovax, Lawrence, Kansas 66047, United States.
  • Lammers T; Institute for Experimental Molecular Imaging, Uniklinik RWTH Aachen and Helmholtz Institute for Biomedical Engineering, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
  • De Geest BG; Institute for Experimental Molecular Imaging, Uniklinik RWTH Aachen and Helmholtz Institute for Biomedical Engineering, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
  • Shi Y; Department of Pharmaceutics, Utrecht University, 3584 CG Utrecht, The Netherlands.
J Am Chem Soc ; 142(28): 12133-12139, 2020 07 15.
Article en En | MEDLINE | ID: mdl-32524819
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Quinolinas / Glicoproteínas de Membrana / Profármacos / Beta-Galactosidasa / Receptor Toll-Like 7 / Receptor Toll-Like 8 / Imidazoles Límite: Animals Idioma: En Revista: J Am Chem Soc Año: 2020 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Quinolinas / Glicoproteínas de Membrana / Profármacos / Beta-Galactosidasa / Receptor Toll-Like 7 / Receptor Toll-Like 8 / Imidazoles Límite: Animals Idioma: En Revista: J Am Chem Soc Año: 2020 Tipo del documento: Article País de afiliación: Alemania