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Optimal priming of poxvirus vector (NYVAC)-based HIV vaccine regimens for T cell responses requires three DNA injections. Results of the randomized multicentre EV03/ANRS VAC20 Phase I/II Trial.
Lévy, Yves; Lacabaratz, Christine; Ellefsen-Lavoie, Kim; Stöhr, Wolfgang; Lelièvre, Jean-Daniel; Bart, Pierre-Alexandre; Launay, Odile; Weber, Jonathan; Salzberger, Bernd; Wiedemann, Aurélie; Surenaud, Mathieu; Koelle, David M; Wolf, Hans; Wagner, Ralf; Rieux, Véronique; Montefiori, David C; Yates, Nicole L; Tomaras, Georgia D; Gottardo, Raphael; Mayer, Bryan; Ding, Song; Thiébaut, Rodolphe; McCormack, Sheena; Chêne, Geneviève; Pantaleo, Giuseppe.
Afiliación
  • Lévy Y; Vaccine Research Institute, Université Paris-Est Créteil, Faculté de Médecine, INSERM U955, équipe 16, Créteil, France.
  • Lacabaratz C; Assistance Publique-Hôpitaux de Paris, Groupe Henri-Mondor Albert-Chenevier, Service d'Immunologie Clinique, Créteil, France.
  • Ellefsen-Lavoie K; Vaccine Research Institute, Université Paris-Est Créteil, Faculté de Médecine, INSERM U955, équipe 16, Créteil, France.
  • Stöhr W; Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
  • Lelièvre JD; MRC Clinical Trials Unit at UCL, London, United Kingdom.
  • Bart PA; Vaccine Research Institute, Université Paris-Est Créteil, Faculté de Médecine, INSERM U955, équipe 16, Créteil, France.
  • Launay O; Assistance Publique-Hôpitaux de Paris, Groupe Henri-Mondor Albert-Chenevier, Service d'Immunologie Clinique, Créteil, France.
  • Weber J; Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
  • Salzberger B; Université de Paris, Faculté de médecine Paris Descartes; Inserm, CIC 1417, F-CRIN I-REIVAC; Assistance Publique-Hôpitaux de Paris, CIC Cochin Pasteur, Paris, France.
  • Wiedemann A; Imperial College London, London, United Kingdom.
  • Surenaud M; University Hospital, Institute of Clinical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany.
  • Koelle DM; Vaccine Research Institute, Université Paris-Est Créteil, Faculté de Médecine, INSERM U955, équipe 16, Créteil, France.
  • Wolf H; Vaccine Research Institute, Université Paris-Est Créteil, Faculté de Médecine, INSERM U955, équipe 16, Créteil, France.
  • Wagner R; Department of Medicine & Department of Global Health, University of Washington, Fred Hutchinson Cancer Research Center Seattle, Washington, United States of America.
  • Rieux V; University Hospital, Institute of Clinical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany.
  • Montefiori DC; University Hospital, Institute of Clinical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany.
  • Yates NL; Vaccine Research Institute, Université Paris-Est Créteil, Faculté de Médecine, INSERM U955, équipe 16, Créteil, France.
  • Tomaras GD; ANRS, Paris, France.
  • Gottardo R; Department of Surgery, Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America.
  • Mayer B; Department of Surgery, Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America.
  • Ding S; Department of Surgery, Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America.
  • Thiébaut R; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
  • McCormack S; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
  • Chêne G; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
  • Pantaleo G; EuroVacc Foundation, Lausanne, Switzerland.
PLoS Pathog ; 16(6): e1008522, 2020 06.
Article en En | MEDLINE | ID: mdl-32589686
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Poxviridae / Antígenos VIH / Vacunas contra el SIDA / Vacunas de ADN / Productos del Gen env del Virus de la Inmunodeficiencia Humana / Vectores Genéticos Tipo de estudio: Clinical_trials Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS Pathog Año: 2020 Tipo del documento: Article País de afiliación: Francia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Poxviridae / Antígenos VIH / Vacunas contra el SIDA / Vacunas de ADN / Productos del Gen env del Virus de la Inmunodeficiencia Humana / Vectores Genéticos Tipo de estudio: Clinical_trials Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS Pathog Año: 2020 Tipo del documento: Article País de afiliación: Francia