Evaluation of anaesthetic and cardiorespiratory effects after intramuscular administration of alfaxalone alone, alfaxalone-ketamine and alfaxalone-butorphanol-medetomidine in common marmosets (Callithrix jacchus).
J Med Primatol
; 49(6): 291-299, 2020 12.
Article
en En
| MEDLINE
| ID: mdl-32654222
ABSTRACT
BACKGROUND:
Anaesthesia is often required in common marmosets undergoing various procedures. The aim of this study was to evaluate anaesthetic and cardiopulmonary effects of alfaxalone, alfaxalone-ketamine and alfaxalone-butorphanol-medetomidine in common marmosets.METHODS:
The following treatments were repeatedly administered to seven female common marmosets Treatment A, alfaxalone (12 mg kg-1 ) alone; treatment AK, alfaxalone (1 mg animal-1 ) plus ketamine (2.5 mg animal-1 ); treatment AMB, alfaxalone (4 mg kg-1 ), medetomidine (50 µg kg-1 ) plus butorphanol (0.3 mg kg-1 ); and treatment AMB-Ati, AMB with atipamezole at 45 minutes. RESULTS ANDCONCLUSIONS:
Marmosets became laterally recumbent and unresponsive for approximately 30 minutes in A and AK and for approximately 60 minutes in AMB. The animals showed rapid recovery following atipamezole injection in AMB-Ati. The decrease in heart rate and SpO2 was significantly greater in AMB compared to A and AK. Oxygen supplementation, anaesthetic monitors and atipamezole should be available especially when AMB is administered.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Pregnanodionas
/
Butorfanol
/
Callithrix
/
Anestésicos Combinados
/
Medetomidina
/
Ketamina
Límite:
Animals
Idioma:
En
Revista:
J Med Primatol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Japón