Transcriptome analysis in mice treated with vigabatrin identifies dysregulation of genes associated with retinal signaling circuitry.

Walters, Dana; Vogel, Kara R; Brown, Madalyn; Shi, Xutong; Roullet, Jean-Baptiste; Gibson, K Michael

Walters, Dana; Vogel, Kara R; Brown, Madalyn; Shi, Xutong; Roullet, Jean-Baptiste; Gibson, K Michael.

Afiliación

Walters D; Department of Pharmacotherapy, Washington State University College of Pharmacy and Pharmaceutical Sciences, Spokane, WA, USA. Electronic address: dcwalters@wsu.edu.
Vogel KR; Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA. Electronic address: krvogel@wisc.edu.
Brown M; Department of Pharmacotherapy, Washington State University College of Pharmacy and Pharmaceutical Sciences, Spokane, WA, USA. Electronic address: madalyn.brown@wsu.edu.
Shi X; Department of Pharmacotherapy, Washington State University College of Pharmacy and Pharmaceutical Sciences, Spokane, WA, USA. Electronic address: xutong.shi@wsu.edu.
Roullet JB; Department of Pharmacotherapy, Washington State University College of Pharmacy and Pharmaceutical Sciences, Spokane, WA, USA. Electronic address: j.roullet@wsu.edu.
Gibson KM; Department of Pharmacotherapy, Washington State University College of Pharmacy and Pharmaceutical Sciences, Spokane, WA, USA. Electronic address: mike.gibson@wsu.edu.

Epilepsy Res ; 166: 106395, 2020 10.

Article en En | MEDLINE | ID: mdl-32679486

Asunto(s)

Anticonvulsivantes/farmacología; Perfilación de la Expresión Génica/métodos; Red Nerviosa/fisiología; Retina/fisiología; Vigabatrin/farmacología; Vías Visuales/fisiología; Animales; Masculino; Ratones; Ratones Endogámicos C57BL; Red Nerviosa/química; Red Nerviosa/efectos de los fármacos; Retina/química; Retina/efectos de los fármacos; Análisis de Secuencia de ARN/métodos; Vías Visuales/química; Vías Visuales/efectos de los fármacos

Palabras clave

Gene expression; RNA sequencing (RNAseq); Retina; Transcriptome; Vigabatrin; Visual field constriction

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Retina / Vías Visuales / Vigabatrin / Perfilación de la Expresión Génica / Anticonvulsivantes / Red Nerviosa Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Epilepsy Res Asunto de la revista: CEREBRO / NEUROLOGIA Año: 2020 Tipo del documento: Article

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