S-adenosyl-L-methionine (SAMe) halts the autoimmune response in patients with primary biliary cholangitis (PBC) via antioxidant and S-glutathionylation processes in cholangiocytes.

Kilanczyk, E; Banales, J M; Wunsch, E; Barbier, O; Avila, M A; Mato, J M; Milkiewicz, M; Milkiewicz, P

Kilanczyk, E; Banales, J M; Wunsch, E; Barbier, O; Avila, M A; Mato, J M; Milkiewicz, M; Milkiewicz, P.

Afiliación

Kilanczyk E; Department of Medical Biology, Pomeranian Medical University, Szczecin, Poland.
Banales JM; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, Ikerbasque, CIBERehd, San Sebastian, Spain.
Wunsch E; Translational Medicine Group, Pomeranian Medical University, Szczecin, Poland.
Barbier O; Laboratory of Molecular Pharmacology, CHU de Québec Research Center, Faculty of Pharmacy, Laval University, Québec City, QC G1V 0A6, Canada.
Avila MA; Hepatology Program, Center for Applied Medical Research (CIMA), University of Navarra and CIBERehd, Pamplona 31008, Spain.
Mato JM; CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Technology, Park of Bizkaia, Derio 48160, Bizkaia, Spain.
Milkiewicz M; Department of Medical Biology, Pomeranian Medical University, Szczecin, Poland. Electronic address: milkiewm@pum.edu.pl.
Milkiewicz P; Translational Medicine Group, Pomeranian Medical University, Szczecin, Poland; Liver and Internal Medicine Unit, Medical University of Warsaw, Warsaw, Poland.

Biochim Biophys Acta Mol Basis Dis ; 1866(11): 165895, 2020 11 01.

Article en En | MEDLINE | ID: mdl-32681864

Asunto(s)

Autoinmunidad/efectos de los fármacos; Colangitis/tratamiento farmacológico; Colangitis/fisiopatología; S-Adenosilmetionina/farmacología; S-Adenosilmetionina/uso terapéutico; Antioxidantes/metabolismo; Células Cultivadas; Colangitis/inmunología; Colestasis/tratamiento farmacológico; Colestasis/metabolismo; Ensayo de Inmunoadsorción Enzimática; Femenino; Glutatión/análogos & derivados; Glutatión/metabolismo; Humanos; Immunoblotting; Inmunohistoquímica; Masculino; Persona de Mediana Edad

Palabras clave

Cholestasis; Hepatoprotection; Primary biliary cholangitis; S-adenosyl-L-methionine; S-glutathionylation

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: S-Adenosilmetionina / Autoinmunidad / Colangitis Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Biochim Biophys Acta Mol Basis Dis Año: 2020 Tipo del documento: Article País de afiliación: Polonia

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