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Development and function of human dendritic cells in humanized mice models.
Anselmi, Giorgio; Helft, Julie; Guermonprez, Pierre.
Afiliación
  • Anselmi G; King's College London, Centre for Inflammation Biology and Cancer Immunology, The Peter Gorer Department of Immunobiology, United Kingdom.
  • Helft J; PSL Research University, Institut Curie Research Center, Immunity and Cancer department, INSERM U932, Paris, France.
  • Guermonprez P; King's College London, Centre for Inflammation Biology and Cancer Immunology, The Peter Gorer Department of Immunobiology, United Kingdom; Université de Paris, Centre for Inflammation Research, CNRS ERL8252, INSERM 1149, Hopital Bichat Claude Bernard, France. Electronic address: pierre.guermonprez@kcl.ac.uk.
Mol Immunol ; 125: 151-161, 2020 09.
Article en En | MEDLINE | ID: mdl-32688117
Dendritic cells (DCs) are sentinel cells of the immune system arising from hematopoietic stem cells. DCs play a key role in the regulation of both adaptive and innate lymphocyte responses. As such, experimental models enabling a thorough analysis of human DCs development and function are needed. Humanized mice models (termed collectively as HIS mice, or human immune system mice models) provide unique opportunities to model human hematopoiesis and tackle the function of human immune cell types in vivo. Here, we review experimental approaches enabling to recapitulate the ontogeny of DC subsets in HIS mice and discuss studies addressing the biology of human DC subsets implementing HIS mice models.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Células Dendríticas / Modelos Animales Límite: Animals / Humans Idioma: En Revista: Mol Immunol Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Células Dendríticas / Modelos Animales Límite: Animals / Humans Idioma: En Revista: Mol Immunol Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido