Your browser doesn't support javascript.
loading
Chlorotoxin-derived bicyclic peptides for targeted imaging of glioblastomas.
Li, Meiqing; Shao, Ximing; Wu, Chunlei; Lu, Danyi; Liu, Ke; Wang, Wei; Liu, Jiakai; Li, Hongchang; Su, Wu; Fang, Lijing.
Afiliación
  • Li M; Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. hc.li@siat.ac.cn wu.su@siat.ac.cn lj.fang@siat.ac.cn and University of Chinese Academy of Sciences, Beijing 100049, C
  • Shao X; Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. hc.li@siat.ac.cn wu.su@siat.ac.cn lj.fang@siat.ac.cn.
  • Wu C; Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. hc.li@siat.ac.cn wu.su@siat.ac.cn lj.fang@siat.ac.cn.
  • Lu D; Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. hc.li@siat.ac.cn wu.su@siat.ac.cn lj.fang@siat.ac.cn.
  • Liu K; Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. hc.li@siat.ac.cn wu.su@siat.ac.cn lj.fang@siat.ac.cn.
  • Wang W; Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. hc.li@siat.ac.cn wu.su@siat.ac.cn lj.fang@siat.ac.cn.
  • Liu J; Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. hc.li@siat.ac.cn wu.su@siat.ac.cn lj.fang@siat.ac.cn.
  • Li H; Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. hc.li@siat.ac.cn wu.su@siat.ac.cn lj.fang@siat.ac.cn.
  • Su W; Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. hc.li@siat.ac.cn wu.su@siat.ac.cn lj.fang@siat.ac.cn.
  • Fang L; Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. hc.li@siat.ac.cn wu.su@siat.ac.cn lj.fang@siat.ac.cn and University of Chinese Academy of Sciences, Beijing 100049, C
Chem Commun (Camb) ; 56(66): 9537-9540, 2020 Aug 19.
Article en En | MEDLINE | ID: mdl-32691026
ABSTRACT
A convenient and efficient strategy was developed for accessing chlorotoxin-derived bicyclic peptide-biomolecule conjugates by cyclizing fully-unprotected linear peptides with a designed tetrafunctional chemical linker. Among these peptides, bicycle-P3 bearing the N-terminal sequence of chlorotoxin shows high tumor selectivity and penetration ability, which is promising for treatment of gliomas.
Asunto(s)
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Péptidos Cíclicos / Venenos de Escorpión / Neoplasias Encefálicas / Glioblastoma / Imagen Óptica Límite: Animals / Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Péptidos Cíclicos / Venenos de Escorpión / Neoplasias Encefálicas / Glioblastoma / Imagen Óptica Límite: Animals / Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article