Into Thin Air: Hypoxia Drives Metabolic and Epigenomic Deregulation of Lethal Pediatric Ependymoma.

Englinger, Bernhard; Hack, Olivia A; Filbin, Mariella G

Englinger, Bernhard; Hack, Olivia A; Filbin, Mariella G.

Afiliación

Englinger B; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Hack OA; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Filbin MG; Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: mariella.filbin@childrens.harvard.edu.

Dev Cell ; 54(2): 134-136, 2020 07 20.

Article en En | MEDLINE | ID: mdl-32693052

ABSTRACT

ABSTRACT

Posterior fossa type A (PFA) ependymoma is a lethal pediatric brain tumor proposed to be driven solely by epigenetic deregulation. Michealraj et al. (2020) demonstrate that hypoxia reprograms PFA metabolism and, subsequently, the epigenome toward H3K27 hypomethylation, mirroring transcriptional and metabolic signatures of gliogenic progenitors involved in embryonal hindbrain development.

Asunto(s)

Neoplasias Encefálicas; Ependimoma; Neoplasias Encefálicas/genética; Niño; Metilación de ADN/genética; Ependimoma/genética; Epigenoma; Epigenómica; Humanos; Hipoxia

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Ependimoma Límite: Child / Humans Idioma: En Revista: Dev Cell Asunto de la revista: EMBRIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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