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High glucose distinctively regulates Ca2+ influx in cytotoxic T lymphocytes upon target recognition and thapsigargin stimulation.
Zou, Huajiao; Yang, Wenjuan; Schwär, Gertrud; Zhao, Renping; Alansary, Dalia; Yin, Deling; Schwarz, Eva C; Niemeyer, Barbara A; Qu, Bin.
Afiliación
  • Zou H; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
  • Yang W; Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.
  • Schwär G; Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.
  • Zhao R; Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.
  • Alansary D; Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.
  • Yin D; Molecular Biophysics, CIPMM, School of Medicine, Saarland University, Homburg, Germany.
  • Schwarz EC; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
  • Niemeyer BA; Department of Internal Medicine, College of Medicine, East Tennessee State University, Johnson City, TN, USA.
  • Qu B; Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany.
Eur J Immunol ; 50(12): 2095-2098, 2020 12.
Article en En | MEDLINE | ID: mdl-32697355
ABSTRACT
In CTLs High glucose-culture enhances thapsigargin-induced SOCE but decreases target recognition-induced Ca2+ influx. High glucose-culture regulates expression of ORAIs and STIMs without affecting glucose uptake. More high glucose-cultured CTLs are prone to necrosis after execution of killing.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Linfocitos T Citotóxicos / Canales de Calcio / Calcio / Tapsigargina / Glucosa Límite: Humans Idioma: En Revista: Eur J Immunol Año: 2020 Tipo del documento: Article País de afiliación: China
Texto completo
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Linfocitos T Citotóxicos / Canales de Calcio / Calcio / Tapsigargina / Glucosa Límite: Humans Idioma: En Revista: Eur J Immunol Año: 2020 Tipo del documento: Article País de afiliación: China