The HLA-B*13:01 and the dapsone hypersensitivity syndrome in Korean and Asian populations: genotype- and meta-analyses.
Expert Opin Drug Saf
; 19(10): 1349-1356, 2020 Oct.
Article
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| MEDLINE
| ID: mdl-32700588
ABSTRACT
BACKGROUND:
The human leukocyte antigen (HLA)-B*1301 was reported as an important risk factor for dapsone hypersensitivity syndrome (DHS) in Chinese and Thai populations. RESEARCH DESIGN ANDMETHODS:
From the Korean nationwide registry, seven subjects with previous DHS were included. Their HLA allele/phenotype frequencies were compared with 8 dapsone-tolerant subjects recruited from a single institution, and general population (n = 485) in Korea. The authors also performed a meta-analysis with these data using previous Chinese and Thai studies.RESULTS:
Among the seven DHS subjects, 85.7% presented with the HLA-B*1301 allele. The HLA-C*0304, HLA-DRB1*1202 (both in linkage disequilibrium with HLA-B*1301), and HLA-A*0201 alleles were also presented in 85.7%, 71.4%, and 71.4%, respectively. Subjects with HLA-B*1301 were susceptible to developing DHS compared to dapsone-tolerant controls (odds ratio [OR] 73.667) and the Korean general population (OR 139.500). HLA-C*0304 (OR 40.935), HLA-DRB*1202 (OR 36.613), and HLA-A*0201 (OR 5.862) showed similar results. In meta-analysis, HLA-B*1301 was associated with dapsone-induced hypersensitivity (overall OR 42.692), and subgroup analyses according to the control types demonstrated similar results (OR43.694 and 41.866, respectively).CONCLUSIONS:
Similar to previous Asian population studies, HLA-B*1301 is significantly associated with the risk of DHS in Korea. These associations may be useful for preventing DHS and improving drug safety.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Dapsona
/
Antígeno HLA-B13
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Síndrome de Hipersensibilidad a Medicamentos
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Leprostáticos
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
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Systematic_reviews
Límite:
Adult
/
Aged
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Child
/
Female
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Humans
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Male
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Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Expert Opin Drug Saf
Asunto de la revista:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Año:
2020
Tipo del documento:
Article