A Macro-Structural Dispersion Characteristic of Brain White Matter and Its Application to Bipolar Disorder.
IEEE Trans Biomed Eng
; 68(2): 428-435, 2021 02.
Article
en En
| MEDLINE
| ID: mdl-32746027
ABSTRACT
OBJECTIVE:
Our goal is to find distinct characteristics of brain white matter in bipolar disorder, of which the development of diagnostic imaging measures is necessary for early diagnosis and prospective studies.METHODS:
Given a tractogram dataset which is a dense set of white matter fiber pathways of the whole brain obtained from diffusion magnetic resonance imaging, we propose to compute a global measure for a voxel from the dispersion statistics of a set of fibers which indicates the complexity of the white matter voxel not locally but at macroscopic scales.RESULTS:
Our findings demonstrate that macro-structural dispersion information is significant for discrimination of the bipolar patients from the healthy controls, particularly in the frontally associative bundles such as cingulum and inferior occipito-frontal fascicles.CONCLUSION:
The proposed measure is as informative as the local diffusion measures for the detection of changes in the white matter regions.SIGNIFICANCE:
Our findings show that the proposed measure is a potential diagnostic imaging marker in bipolar disorder and the proposed novel dispersion map of the brain could be used for other neurological applications.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Trastorno Bipolar
/
Sustancia Blanca
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Humans
Idioma:
En
Revista:
IEEE Trans Biomed Eng
Año:
2021
Tipo del documento:
Article