Primary extragonadal vaginal yolk sac tumour: A case report.
Malays J Pathol
; 42(2): 301-305, 2020 Aug.
Article
en En
| MEDLINE
| ID: mdl-32860387
ABSTRACT
INTRODUCTION:
Yolk sac tumour (YST) or endodermal sinus tumour is rare and typically seen in gonads. CASE REPORT We described a case of extragonadal vaginal YST in a one year and seven months old girl who presented with vaginal discharge and bleeding, and discuss its differential diagnosis and potential pitfalls in immunohistochemistry. She was found to have a suprapubic mass on examination. The serum alpha fetoprotein was 11919.4 ng/mL. Computed tomography of the pelvis revealed a large 6.4 cm heterogenous pelvic mass. Colposcopic examination of the pelvis showed a fungating vaginal mass that was subsequently confirmed as a yolk sac tumour. Immunohistochemically, the malignant cells were positive toward CKAE1/AE3, AFP and glypican-3, as well as CD117.DISCUSSION:
Solid pattern extragonadal vaginal YST may morphologically resemble dysgerminoma that is also CD117 positive, while the glandular pattern YST may have clear cytoplasm and is positive for cytokeratin; hence, may resemble clear cell carcinoma. Being mindful of these potential diagnostic caveats is necessary to prevent misdiagnosis.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Vaginales
/
Tumor del Seno Endodérmico
Tipo de estudio:
Diagnostic_studies
Límite:
Female
/
Humans
/
Infant
Idioma:
En
Revista:
Malays J Pathol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Malasia