Lesson of the month: novel method to quantify neutrophil uptake in early lung cancer using SPECT-CT.
Thorax
; 75(11): 1020-1023, 2020 11.
Article
en En
| MEDLINE
| ID: mdl-32887739
ABSTRACT
Neutrophils play an important role in the lung tumour microenvironment. We hypothesised that radiolabelled neutrophils coupled to single-photon emission CT (SPECT) may non-invasively quantify neutrophil uptake in tumours from patients with non-small cell lung cancer. We demonstrated increased uptake of radiolabelled neutrophils from the blood into tumours compared with non-specific uptake using radiolabelled transferrin. Moreover, indium-111-neutrophil activity in the tumour biopsies also correlated with myeloperoxidase (MPO)-positive neutrophils. Our data support the utility of imaging with In-111-labelled neutrophils and SPECT-CT to quantify neutrophil uptake in lung cancer.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tomografía Computarizada de Emisión de Fotón Único
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Neoplasias Pulmonares
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Neutrófilos
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Thorax
Año:
2020
Tipo del documento:
Article
País de afiliación:
Reino Unido