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Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors.
Huang, Shih-Chung; Adhikari, Sharmila; Brownell, James E; Calderwood, Emily F; Chouitar, Jouhara; D'Amore, Natalie Roy; England, Dylan B; Foley, Klaudia; Harrison, Sean J; LeRoy, Patrick J; Lok, David; Lublinsky, Anna; Ma, Li-Ting; Menon, Saurabh; Yang, Yu; Zhang, Ji; Gould, Alexandra E.
Afiliación
  • Huang SC; Takeda Pharmaceuticals International Co., 40 Landsdowne Street, Cambridge, MA 02139, United States. Electronic address: sampson.huang@takeda.com.
  • Adhikari S; Takeda Pharmaceuticals International Co., 40 Landsdowne Street, Cambridge, MA 02139, United States.
  • Brownell JE; Takeda Pharmaceuticals International Co., 40 Landsdowne Street, Cambridge, MA 02139, United States.
  • Calderwood EF; Takeda Pharmaceuticals International Co., 40 Landsdowne Street, Cambridge, MA 02139, United States.
  • Chouitar J; Takeda Pharmaceuticals International Co., 40 Landsdowne Street, Cambridge, MA 02139, United States.
  • D'Amore NR; Takeda Pharmaceuticals International Co., 40 Landsdowne Street, Cambridge, MA 02139, United States.
  • England DB; Takeda Pharmaceuticals International Co., 40 Landsdowne Street, Cambridge, MA 02139, United States.
  • Foley K; Takeda Pharmaceuticals International Co., 40 Landsdowne Street, Cambridge, MA 02139, United States.
  • Harrison SJ; Takeda Pharmaceuticals International Co., 40 Landsdowne Street, Cambridge, MA 02139, United States.
  • LeRoy PJ; Takeda Pharmaceuticals International Co., 40 Landsdowne Street, Cambridge, MA 02139, United States.
  • Lok D; Takeda Pharmaceuticals International Co., 40 Landsdowne Street, Cambridge, MA 02139, United States.
  • Lublinsky A; Takeda Pharmaceuticals International Co., 40 Landsdowne Street, Cambridge, MA 02139, United States.
  • Ma LT; Takeda Pharmaceuticals International Co., 40 Landsdowne Street, Cambridge, MA 02139, United States.
  • Menon S; Takeda Pharmaceuticals International Co., 40 Landsdowne Street, Cambridge, MA 02139, United States.
  • Yang Y; Takeda Pharmaceuticals International Co., 40 Landsdowne Street, Cambridge, MA 02139, United States.
  • Zhang J; Takeda Pharmaceuticals International Co., 40 Landsdowne Street, Cambridge, MA 02139, United States.
  • Gould AE; Takeda Pharmaceuticals International Co., 40 Landsdowne Street, Cambridge, MA 02139, United States.
Bioorg Med Chem ; 28(19): 115681, 2020 10 01.
Article en En | MEDLINE | ID: mdl-32912429
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Ácidos Sulfónicos / Descubrimiento de Drogas / Proteína 7 Relacionada con la Autofagia Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Ácidos Sulfónicos / Descubrimiento de Drogas / Proteína 7 Relacionada con la Autofagia Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article