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Design and Characterization of a Minimally Invasive Bipolar Electrode for Electroporation.
Merola, Giulia; Fusco, Roberta; Di Bernardo, Elio; D'Alessio, Valeria; Izzo, Francesco; Granata, Vincenza; Contartese, Deyanira; Cadossi, Matteo; Audenino, Alberto; Perazzolo Gallo, Giacomo.
Afiliación
  • Merola G; Oncology Medical and Research & Development Division, Igea SpA, 41012 Carpi, Italy.
  • Fusco R; Oncology Medical and Research & Development Division, Igea SpA, 41012 Carpi, Italy.
  • Di Bernardo E; Oncology Medical and Research & Development Division, Igea SpA, 41012 Carpi, Italy.
  • D'Alessio V; Oncology Medical and Research & Development Division, Igea SpA, 41012 Carpi, Italy.
  • Izzo F; Hepatobiliary Surgical Oncology Unit, "Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli", 80131 Naples, Italy.
  • Granata V; Radiology Unit, "Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli", 80131 Naples, Italy.
  • Contartese D; Complex Structure of Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136 Bologna, Italy.
  • Cadossi M; Oncology Medical and Research & Development Division, Igea SpA, 41012 Carpi, Italy.
  • Audenino A; Department of Mechanical and Aerospace Engineering, Politecnico di Torino, 10138 Turin, Italy.
  • Perazzolo Gallo G; Oncology Medical and Research & Development Division, Igea SpA, 41012 Carpi, Italy.
Biology (Basel) ; 9(9)2020 Sep 21.
Article en En | MEDLINE | ID: mdl-32967343
OBJECTIVE: To test a new bipolar electrode for electroporation consisting of a single minimally invasive needle. METHODS: A theoretical study was performed by using Comsol Multiphysics® software. The prototypes of electrode have been tested on potatoes and pigs, adopting an irreversible electroporation protocol. Different applied voltages and different geometries of bipolar electrode prototype have been evaluated. RESULTS: Simulations and pre-clinical tests have shown that the volume of ablated area is mainly influenced by applied voltage, while the diameter of the electrode had a lesser impact, making the goal of minimal-invasiveness possible. The conductive pole's length determined an increase of electroporated volume, while the insulated pole length inversely affects the electroporated volume size and shape; when the insulated pole length decreases, a more regular shape of the electric field is obtained. Moreover, the geometry of the electrode determined a different shape of the electroporated volume. A parenchymal damage in the liver of pigs due to irreversible electroporation protocol was observed. CONCLUSION: The minimally invasive bipolar electrode is able to treat an electroporated volume of about 10 mm in diameter by using a single-needle electrode. Moreover, the geometry and the electric characteristics can be selected to produce ellipsoidal ablation volumes.
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Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Revista: Biology (Basel) Año: 2020 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Revista: Biology (Basel) Año: 2020 Tipo del documento: Article País de afiliación: Italia