Distributions of intravenous injected iodine nanoparticles in orthotopic u87 human glioma xenografts over time and tumor therapy.
Nanomedicine (Lond)
; 15(24): 2369-2383, 2020 10.
Article
en En
| MEDLINE
| ID: mdl-32975163
ABSTRACT
Aim:
To analyze the localization, distribution and effect of iodine nanoparticles (INPs) on radiation therapy (RT) in advanced intracerebral gliomas over time after intravenous injection. Materials &methods:
Luciferase/td-tomato expressing U87 human glioma cells were implanted into mice which were injected intravenously with INPs. Mice with gliomas were followed for tumor progression and survival. Immune-stained mouse brain sections were examined and quantified by confocal fluorescence microscopy.Results:
INPs injected intravenously 3 days prior to RT, compared with 1 day, showed greater association with CD31-staining structures, accumulated inside tumor cells more, covered more of the tumor cell surface and trended toward increased median survival.Conclusion:
INP persistence and redistribution in tumors over time may enable greater RT enhancement and clinically relevant hypo-fractionated-RT and may enhance INP efficacy.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Encefálicas
/
Nanopartículas
/
Glioma
/
Yodo
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nanomedicine (Lond)
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos