Identification of Autophagy-Inhibiting Factors of Mycobacterium tuberculosis by High-Throughput Loss-of-Function Screening.

Strong, Emily J; Jurcic Smith, Kristen L; Saini, Neeraj K; Ng, Tony W; Porcelli, Steven A; Lee, Sunhee

Strong, Emily J; Jurcic Smith, Kristen L; Saini, Neeraj K; Ng, Tony W; Porcelli, Steven A; Lee, Sunhee.

Afiliación

Strong EJ; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Jurcic Smith KL; Human Vaccine Institute, Duke University, Durham, North Carolina, USA.
Saini NK; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Ng TW; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Porcelli SA; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Lee S; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.

Infect Immun ; 88(12)2020 11 16.

Article en En | MEDLINE | ID: mdl-32989037

Asunto(s)

Autofagia; Proteínas Bacterianas/genética; Farmacorresistencia Bacteriana/genética; Interacciones Microbiota-Huesped/inmunología; Macrófagos/metabolismo; Mycobacterium tuberculosis/genética; Tuberculosis/metabolismo; Animales; Proteínas Bacterianas/metabolismo; Biblioteca de Genes; Ensayos Analíticos de Alto Rendimiento; Interacciones Microbiota-Huesped/genética; Inmunidad Innata; Interleucina-1beta/metabolismo; Macrófagos/microbiología; Ratones; Mycobacterium smegmatis/fisiología; Mycobacterium tuberculosis/efectos de los fármacos; Mycobacterium tuberculosis/inmunología; Células RAW 264.7; Serina-Treonina Quinasas TOR/metabolismo; Tuberculosis/genética; Tuberculosis/microbiología; Factor de Necrosis Tumoral alfa/metabolismo; Factores de Virulencia/genética

Palabras clave

Mycobacterium tuberculosis; PE/PPE proteins; autophagy; high-throughput screen; host-pathogen interactions; innate immunity; intracellular growth

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Autofagia / Proteínas Bacterianas / Tuberculosis / Farmacorresistencia Bacteriana / Interacciones Microbiota-Huesped / Macrófagos / Mycobacterium tuberculosis Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Animals Idioma: En Revista: Infect Immun Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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