L-Citrulline Level and Transporter Activity Are Altered in Experimental Models of Amyotrophic Lateral Sclerosis.

Gyawali, Asmita; Gautam, Shashi; Hyeon, Seung Jae; Ryu, Hoon; Kang, Young-Sook

Gyawali, Asmita; Gautam, Shashi; Hyeon, Seung Jae; Ryu, Hoon; Kang, Young-Sook.

Afiliación

Gyawali A; College of Pharmacy and Drug Information Research Institute, Sookmyung Women's University, Seoul, Republic of Korea.
Gautam S; College of Pharmacy and Drug Information Research Institute, Sookmyung Women's University, Seoul, Republic of Korea.
Hyeon SJ; Laboratory for Brain Gene Regulation and Epigenetics, Center for Neuroscience, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.
Ryu H; Laboratory for Brain Gene Regulation and Epigenetics, Center for Neuroscience, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea.
Kang YS; Boston University Alzheimer's Disease Center Department of Neurology, Boston University School of Medicine, Boston, MA, 02183, USA.

Mol Neurobiol ; 58(2): 647-657, 2021 Feb.

Article en En | MEDLINE | ID: mdl-33000451

Asunto(s)

Esclerosis Amiotrófica Lateral/metabolismo; Citrulina/metabolismo; Proteínas de Transporte de Membrana/metabolismo; Sistema de Transporte de Aminoácidos y+L/metabolismo; Animales; Astrocitos/metabolismo; Transporte Biológico; Radioisótopos de Carbono; Línea Celular; Modelos Animales de Enfermedad; Humanos; Cinética; Transportador de Aminoácidos Neutros Grandes 1/metabolismo; Ratones Transgénicos; ARN Mensajero/genética; ARN Mensajero/metabolismo; ARN Interferente Pequeño/metabolismo; Sodio/metabolismo; Médula Espinal/metabolismo; Médula Espinal/patología; Regulación hacia Arriba

Palabras clave

Amyotrophic lateral sclerosis (ALS); Carrier mediated transporter; L-citrulline; LAT1 (large neutral amino acid transporter 1); Motor neuron disease; NSC-34 cells

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas de Transporte de Membrana / Citrulina / Esclerosis Amiotrófica Lateral Límite: Animals / Humans Idioma: En Revista: Mol Neurobiol Asunto de la revista: BIOLOGIA MOLECULAR / NEUROLOGIA Año: 2021 Tipo del documento: Article

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