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Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness.
Gyimesi, Máté; Horváth, Ádám I; Túrós, Demeter; Suthar, Sharad Kumar; Pénzes, Máté; Kurdi, Csilla; Canon, Louise; Kikuti, Carlos; Ruppel, Kathleen M; Trivedi, Darshan V; Spudich, James A; Lorincz, István; Rauscher, Anna Á; Kovács, Mihály; Pál, Endre; Komoly, Sámuel; Houdusse, Anne; Málnási-Csizmadia, András.
Afiliación
  • Gyimesi M; MTA-ELTE Motor Pharmacology Research Group, Pázmány Péter sétány 1/c, 1117 Budapest, Hungary; Motorpharma, Ltd., Szilágyi Erzsébet fasor 27, 1026 Budapest, Hungary. Electronic address: mate.gyimesi@elte.hu.
  • Horváth ÁI; MTA-ELTE Motor Pharmacology Research Group, Pázmány Péter sétány 1/c, 1117 Budapest, Hungary.
  • Túrós D; MTA-ELTE Motor Pharmacology Research Group, Pázmány Péter sétány 1/c, 1117 Budapest, Hungary.
  • Suthar SK; MTA-ELTE Motor Pharmacology Research Group, Pázmány Péter sétány 1/c, 1117 Budapest, Hungary; Printnet, Ltd., Kisgömb utca 25-27, 1135 Budapest, Hungary.
  • Pénzes M; MTA-ELTE Motor Pharmacology Research Group, Pázmány Péter sétány 1/c, 1117 Budapest, Hungary.
  • Kurdi C; MTA-ELTE Motor Pharmacology Research Group, Pázmány Péter sétány 1/c, 1117 Budapest, Hungary.
  • Canon L; Structural Motility, Institut Curie, Paris Université Sciences et Lettres, Sorbonne Université, CNRS UMR144, 75005 Paris, France.
  • Kikuti C; Structural Motility, Institut Curie, Paris Université Sciences et Lettres, Sorbonne Université, CNRS UMR144, 75005 Paris, France.
  • Ruppel KM; Department of Biochemistry, Stanford University School of Medicine, Beckman Center B400, 279 W. Campus Drive, Stanford, CA 94305, USA.
  • Trivedi DV; Department of Biochemistry, Stanford University School of Medicine, Beckman Center B400, 279 W. Campus Drive, Stanford, CA 94305, USA.
  • Spudich JA; Department of Biochemistry, Stanford University School of Medicine, Beckman Center B400, 279 W. Campus Drive, Stanford, CA 94305, USA.
  • Lorincz I; Printnet, Ltd., Kisgömb utca 25-27, 1135 Budapest, Hungary.
  • Rauscher AÁ; MTA-ELTE Motor Pharmacology Research Group, Pázmány Péter sétány 1/c, 1117 Budapest, Hungary; Motorpharma, Ltd., Szilágyi Erzsébet fasor 27, 1026 Budapest, Hungary.
  • Kovács M; MTA-ELTE Motor Pharmacology Research Group, Pázmány Péter sétány 1/c, 1117 Budapest, Hungary; Department of Biochemistry, Eötvös Loránd University, Pázmány Péter sétány 1/c, 1117 Budapest, Hungary and Brunszvik u. 2, 2462 Martonvásár, Hungary.
  • Pál E; Department of Neurology, University of Pécs, Rét utca 2, 7623 Pécs, Hungary.
  • Komoly S; Department of Neurology, University of Pécs, Rét utca 2, 7623 Pécs, Hungary.
  • Houdusse A; Structural Motility, Institut Curie, Paris Université Sciences et Lettres, Sorbonne Université, CNRS UMR144, 75005 Paris, France.
  • Málnási-Csizmadia A; MTA-ELTE Motor Pharmacology Research Group, Pázmány Péter sétány 1/c, 1117 Budapest, Hungary; Department of Biochemistry, Eötvös Loránd University, Pázmány Péter sétány 1/c, 1117 Budapest, Hungary and Brunszvik u. 2, 2462 Martonvásár, Hungary. Electronic address: malna@elte.hu.
Cell ; 183(2): 335-346.e13, 2020 10 15.
Article en En | MEDLINE | ID: mdl-33035452
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Músculo Esquelético / Miosinas del Músculo Esquelético Límite: Adult / Animals / Female / Humans / Male Idioma: En Revista: Cell Año: 2020 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Músculo Esquelético / Miosinas del Músculo Esquelético Límite: Adult / Animals / Female / Humans / Male Idioma: En Revista: Cell Año: 2020 Tipo del documento: Article