UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.

Sun, Jingyuan; Zhu, Zhenru; Li, Wenwen; Shen, Mengying; Cao, Chuanhui; Sun, Qingcan; Guo, Zeqin; Liu, Li; Wu, Dehua

Sun, Jingyuan; Zhu, Zhenru; Li, Wenwen; Shen, Mengying; Cao, Chuanhui; Sun, Qingcan; Guo, Zeqin; Liu, Li; Wu, Dehua.

Afiliación

Sun J; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Zhu Z; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Li W; Hepatology Unit and Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Shen M; Hepatology Unit and Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Cao C; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Sun Q; Hepatology Unit and Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Guo Z; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Liu L; Hepatology Unit and Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. liuli@i.smu.edu.cn.
Wu D; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. 18602062748@163.com.

J Exp Clin Cancer Res ; 39(1): 222, 2020 Oct 21.

Article en En | MEDLINE | ID: mdl-33087136

Asunto(s)

Carcinoma Hepatocelular/patología; Quinasa 1 Reguladora del Ciclo Celular (Checkpoint 1)/metabolismo; Histonas/metabolismo; Neoplasias Hepáticas/patología; Tolerancia a Radiación; Enzimas Ubiquitina-Conjugadoras/metabolismo; Ubiquitinación; Animales; Apoptosis; Biomarcadores de Tumor; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/metabolismo; Carcinoma Hepatocelular/radioterapia; Ciclo Celular; Proliferación Celular; Quinasa 1 Reguladora del Ciclo Celular (Checkpoint 1)/genética; Daño del ADN; Reparación del ADN; Regulación Neoplásica de la Expresión Génica; Histonas/genética; Humanos; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/radioterapia; Ratones; Ratones Desnudos; Fosforilación; Pronóstico; Radioterapia; Tasa de Supervivencia; Células Tumorales Cultivadas; Enzimas Ubiquitina-Conjugadoras/genética; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

Cell cycle arrest; H2AX monoubiquitination; Hepatocellular carcinoma; Radioresistance; Ubiquitin-conjugating enzyme E2T

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tolerancia a Radiación / Histonas / Carcinoma Hepatocelular / Enzimas Ubiquitina-Conjugadoras / Ubiquitinación / Quinasa 1 Reguladora del Ciclo Celular (Checkpoint 1) / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Exp Clin Cancer Res Año: 2020 Tipo del documento: Article País de afiliación: China

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