Benzobicyclo[3.2.1]octene Derivatives as a New Class of Cholinesterase Inhibitors.

Cadez, Tena; Grgicevic, Ana; Ahmetovic, Ramiza; Baric, Danijela; Hrvat, Nikolina Macek; Kovarik, Zrinka; Skoric, Irena

Cadez, Tena; Grgicevic, Ana; Ahmetovic, Ramiza; Baric, Danijela; Hrvat, Nikolina Macek; Kovarik, Zrinka; Skoric, Irena.

Afiliación

Cadez T; Institute for Medical Research and Occupational Health, Ksaverska Cesta 2, 10000 Zagreb, Croatia.
Grgicevic A; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulicev trg 19, 10000 Zagreb, Croatia.
Ahmetovic R; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulicev trg 19, 10000 Zagreb, Croatia.
Baric D; Division of Physical Chemistry, Rudjer Boskovic Institute, Bijenicka Cesta 54, 10000 Zagreb, Croatia.
Hrvat NM; Institute for Medical Research and Occupational Health, Ksaverska Cesta 2, 10000 Zagreb, Croatia.
Kovarik Z; Institute for Medical Research and Occupational Health, Ksaverska Cesta 2, 10000 Zagreb, Croatia.
Skoric I; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulicev trg 19, 10000 Zagreb, Croatia.

Molecules ; 25(21)2020 Oct 22.

Article en En | MEDLINE | ID: mdl-33105595

Asunto(s)

Acetilcolinesterasa/metabolismo; Butirilcolinesterasa/metabolismo; Inhibidores de la Colinesterasa/síntesis química; Ciclooctanos/química; Bibliotecas de Moléculas Pequeñas/síntesis química; Acilación; Bencilaminas/química; Inhibidores de la Colinesterasa/metabolismo; Teoría Funcional de la Densidad; Compuestos Epoxi/química; Éter/química; Humanos; Concentración 50 Inhibidora; Simulación del Acoplamiento Molecular; Oximas/química; Relación Estructura-Actividad

Palabras clave

acylation; benzobicyclo[3.2.1]octane/octene; benzylamines; cholinesterase; epoxidation; oximes

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Acetilcolinesterasa / Butirilcolinesterasa / Inhibidores de la Colinesterasa / Ciclooctanos / Bibliotecas de Moléculas Pequeñas Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Croacia

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