Inhibiting the Piezo1 channel protects microglia from acute hyperglycaemia damage through the JNK1 and mTOR signalling pathways.

Liu, Hailin; Bian, Wengong; Yang, Dongxia; Yang, Mingmin; Luo, Heguo

Liu, Hailin; Bian, Wengong; Yang, Dongxia; Yang, Mingmin; Luo, Heguo.

Afiliación

Liu H; Department of Anesthesiology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, China; Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, The Third Affiliated Hospital of Nanchang University, Nanchang, China; Graduate School of School of Medicine, Nanc
Bian W; Department of Anesthesiology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, China; Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, The Third Affiliated Hospital of Nanchang University, Nanchang, China; Graduate School of School of Medicine, Nanc
Yang D; Department of Anesthesiology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, China; Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, The Third Affiliated Hospital of Nanchang University, Nanchang, China; Graduate School of School of Medicine, Nanc
Yang M; Department of Anesthesiology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, China.
Luo H; Department of Anesthesiology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, China. Electronic address: cdtg0120@163.com.

Life Sci ; 264: 118667, 2021 Jan 01.

Article en En | MEDLINE | ID: mdl-33127514

Asunto(s)

Hiperglucemia/metabolismo; Hiperglucemia/patología; Canales Iónicos/antagonistas & inhibidores; Microglía/metabolismo; Microglía/patología; Proteína Quinasa 8 Activada por Mitógenos/metabolismo; Transducción de Señal; Serina-Treonina Quinasas TOR/metabolismo; Enfermedad Aguda; Animales; Calcio/metabolismo; Línea Celular; Citosol/metabolismo; Glucosa/toxicidad; Mediadores de Inflamación/metabolismo; Canales Iónicos/metabolismo; Lipopolisacáridos; Ratones; Microglía/efectos de los fármacos; Transducción de Señal/efectos de los fármacos

Palabras clave

Acute hyperglycaemia; Ca(2+) signal; Functional impairment; Inflammation; Microglia; Piezo type mechanosensitive ion channel component 1

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Microglía / Proteína Quinasa 8 Activada por Mitógenos / Serina-Treonina Quinasas TOR / Hiperglucemia / Canales Iónicos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Life Sci Año: 2021 Tipo del documento: Article

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