Clinical Features and Outcomes of Peripartum Cardiomyopathy in Nigeria.

ABSTRACT

BACKGROUND: Nigeria has the highest incidence of peripartum cardiomyopathy (PPCM) in the world. However, data on PPCM-related outcomes are limited. OBJECTIVES: The purpose of this study was to examine the clinical profile, myocardial remodeling, and survival of patients with PPCM in Nigeria. METHODS: This study consecutively recruited 244 PPCM patients (median 7 months postpartum) at 14 sites in Nigeria and applied structured follow-up for a median of 17 months (interquartile range 14 to 20 months). Left ventricular reverse remodeling (LVRR) was defined as the composite of left ventricular (LV) end-diastolic dimension <33 mm/m2 and absolute increase in left ventricular ejection fraction (LVEF) ≥10%. LV full recovery was defined as LVEF ≥55%. RESULTS: Overall, 45 (18.7%) patients died during follow-up. Maternal age <20 years (hazard ratio [HR] 2.40; 95% confidence interval (CI) 1.27 to 4.54), hypotension (HR 1.87; 95% CI 1.02 to 3.43), tachycardia (HR 2.38; 95% CI 1.05 to 5.43), and LVEF <25% at baseline (HR 2.11; 95% CI 1.12 to 3.95) independently predicted mortality. Obesity (HR 0.16; 95% CI 0.04 to 0.55) and regular use of beta-blockers at 6-month follow-up (HR 0.20; 95% CI 0.09 to 0.41) were independently associated with reduced risk for mortality. In total, 48 patients (24.1%) achieved LVRR and 45 (22.6%) achieved LV full recovery. LVEF <25% at baseline (HR 0.66; 95% CI 0.47 to 0.92) and regular use of beta-blockers at 6-month follow-up (HR 1.62; 95% CI 1.17 to 2.25) independently determined the risk for LV full recovery. Progressive reverse remodeling of all cardiac chambers was observed. In total, 18 patients (7.4%) were hospitalized during the study. CONCLUSIONS: This is the largest study of PPCM in Africa. Consistent with late presentations, the mortality rate was high, whereas frequencies of LVRR and LV full recovery were low. Several variables predicted poor outcomes, and regular use of beta-blockers correlated with late survival and LV functional recovery.