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Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis-Addicted Breast Tumor Growth.
Geeraerts, Shauni Lien; Kampen, Kim Rosalie; Rinaldi, Gianmarco; Gupta, Purvi; Planque, Mélanie; Louros, Nikolaos; Heylen, Elien; De Cremer, Kaat; De Brucker, Katrijn; Vereecke, Stijn; Verbelen, Benno; Vermeersch, Pieter; Schymkowitz, Joost; Rousseau, Frederic; Cassiman, David; Fendt, Sarah-Maria; Voet, Arnout; Cammue, Bruno P A; Thevissen, Karin; De Keersmaecker, Kim.
Afiliación
  • Geeraerts SL; Laboratory for Disease Mechanisms in Cancer, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.
  • Kampen KR; Centre of Microbial and Plant Genetics - Plant Fungi Interactions (CMPG-PFI), KU Leuven, Heverlee, Belgium.
  • Rinaldi G; Laboratory for Disease Mechanisms in Cancer, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.
  • Gupta P; Maastricht University Medical Center, Department of Radiation Oncology (MAASTRO), GROW School for Oncology and Developmental Biology, Maastricht, the Netherlands.
  • Planque M; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB Leuven, Leuven, Belgium.
  • Louros N; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.
  • Heylen E; Department of Chemistry, KU Leuven, Heverlee, Belgium.
  • De Cremer K; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB Leuven, Leuven, Belgium.
  • De Brucker K; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.
  • Vereecke S; Switch Laboratory, VIB Center for Brain and Disease Research, VIB-KU Leuven, Leuven, Belgium.
  • Verbelen B; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
  • Vermeersch P; Laboratory for Disease Mechanisms in Cancer, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.
  • Schymkowitz J; Centre of Microbial and Plant Genetics - Plant Fungi Interactions (CMPG-PFI), KU Leuven, Heverlee, Belgium.
  • Rousseau F; Centre of Microbial and Plant Genetics - Plant Fungi Interactions (CMPG-PFI), KU Leuven, Heverlee, Belgium.
  • Cassiman D; Laboratory for Disease Mechanisms in Cancer, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.
  • Fendt SM; Laboratory for Disease Mechanisms in Cancer, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.
  • Voet A; Department of Cardiovascular Sciences, University Hospitals Leuven, Leuven, Belgium.
  • Cammue BPA; Switch Laboratory, VIB Center for Brain and Disease Research, VIB-KU Leuven, Leuven, Belgium.
  • Thevissen K; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
  • De Keersmaecker K; Switch Laboratory, VIB Center for Brain and Disease Research, VIB-KU Leuven, Leuven, Belgium.
Mol Cancer Ther ; 20(1): 50-63, 2021 01.
Article en En | MEDLINE | ID: mdl-33203732
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Serina / Glicina Hidroximetiltransferasa / Neoplasias de la Mama / Sertralina / Reposicionamiento de Medicamentos / Glicina / Antidepresivos Límite: Animals / Female / Humans Idioma: En Revista: Mol Cancer Ther Asunto de la revista: ANTINEOPLASICOS Año: 2021 Tipo del documento: Article País de afiliación: Bélgica
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Serina / Glicina Hidroximetiltransferasa / Neoplasias de la Mama / Sertralina / Reposicionamiento de Medicamentos / Glicina / Antidepresivos Límite: Animals / Female / Humans Idioma: En Revista: Mol Cancer Ther Asunto de la revista: ANTINEOPLASICOS Año: 2021 Tipo del documento: Article País de afiliación: Bélgica