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Multi-Cellular Functions of MG53 in Muscle Calcium Signaling and Regeneration.
Benissan-Messan, Dathe Z; Zhu, Hua; Zhong, Weina; Tan, Tao; Ma, Jianjie; Lee, Peter H U.
Afiliación
  • Benissan-Messan DZ; Department of Surgery, The Ohio State University, Columbus, OH, United States.
  • Zhu H; Department of Surgery, The Ohio State University, Columbus, OH, United States.
  • Zhong W; Department of Surgery, The Ohio State University, Columbus, OH, United States.
  • Tan T; Department of Surgery, The Ohio State University, Columbus, OH, United States.
  • Ma J; Department of Surgery, The Ohio State University, Columbus, OH, United States.
  • Lee PHU; Department of Surgery, The Ohio State University, Columbus, OH, United States.
Front Physiol ; 11: 583393, 2020.
Article en En | MEDLINE | ID: mdl-33240103
ABSTRACT
Since its identification in 2009, multiple studies have indicated the importance of MG53 in muscle physiology. The protein is produced in striated muscles but has physiologic implications reaching beyond the confines of striated muscles. Roles in muscle regeneration, calcium homeostasis, excitation-contraction coupling, myogenesis, and the mitochondria highlight the protein's wide-reaching impact. Numerous therapeutic applications could potentially emerge from these physiologic roles. This review summarizes the current literature regarding the role of MG53 in the skeletal muscle. Therapeutic applications are discussed.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Front Physiol Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Front Physiol Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos