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Characteristic of Oral Squamous Cell Carcinoma Tissues Using Isotope Ratio Mass Spectrometry.
Bogusiak, Katarzyna; Puch, Aleksandra; Mostowski, Radoslaw; Kozakiewicz, Marcin; Paneth, Piotr; Kobos, Józef.
Afiliación
  • Bogusiak K; Department of Maxillofacial Surgery, Medical University of Lodz, 1 Gen. J. Hallera Pl., 90-647 Lodz, Poland.
  • Puch A; Department of Maxillofacial Surgery, Medical University of Lodz, 1 Gen. J. Hallera Pl., 90-647 Lodz, Poland.
  • Mostowski R; Institute of Food Technology and Analysis, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, 4/10 Stefanowskiego street, 90-924 Lodz, Poland.
  • Kozakiewicz M; Department of Maxillofacial Surgery, Medical University of Lodz, 1 Gen. J. Hallera Pl., 90-647 Lodz, Poland.
  • Paneth P; Institute of Applied Radiation Chemistry, Lodz University of Technology, 116 Zeromskiego, 90-924 Lodz, Poland.
  • Kobos J; Department of Histology and Embriology, Medical University of Lodz, 7/9 Zeligowskiego Street, 90-752 Lódz, Poland.
J Clin Med ; 9(11)2020 Nov 22.
Article en En | MEDLINE | ID: mdl-33266376
Overall prognosis for patients with oral squamous cell carcinomas (OSSC) is still unfavourable. However, there is a hope that a novel diagnostic method may establish better cancer biology characteristics. The aim of this study was to evaluate the isotope ratio of nitrogen and carbon in OSSC as compared to margin and healthy tissue. A total of 18 patients with OSSC were included in the study. Specimens collected covered: four tumour, four margin and two healthy oral mucosa samples. The samples underwent further procedures: lyophilization and isotope ratio mass spectrometry. Measurements of the ratio of stable isotopes of nitrogen 15N/14N and carbon 13C/12C were performed. It is noticeable that the highest average nitrogen concentration was observed in tumour 12 ± 0.4% and the lowest in healthy tissues 8 ± 0.9% (p < 0.00001). The highest average carbon content was observed in healthy tissues 57 ± 2.2% and the lowest in tumour 46 ± 1.3% (p < 0.00001). Moreover, values of 15N/14N expressed in delta notation were the highest in healthy tissues 9.84 ± 0.61 and the lowest in tumour 8.92 ± 0.58. Values of 13C/12C tended to be higher in tumour -22.2 ± 0.89 and the lowest in healthy tissues -23.7 ± 1.2. Tumour tissues differ in isotopic composition from tissues taken from margin and healthy tissues taken from distant oral mucosa.
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Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: J Clin Med Año: 2020 Tipo del documento: Article País de afiliación: Polonia

Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: J Clin Med Año: 2020 Tipo del documento: Article País de afiliación: Polonia