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Synthesis and Biological Evaluation of Halogenated E-Stilbenols as Promising Antiaging Agents.
Di Filippo, Ester Sara; Giampietro, Letizia; De Filippis, Barbara; Balaha, Marwa; Ferrone, Vincenzo; Locatelli, Marcello; Pietrangelo, Tiziana; Tartaglia, Angela; Amoroso, Rosa; Fulle, Stefania.
Afiliación
  • Di Filippo ES; Department of Neuroscience Imaging and Clinical Sciences, Interuniversity Institute of Myology, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
  • Giampietro L; Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
  • De Filippis B; Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
  • Balaha M; Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
  • Ferrone V; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafr El Sheikh 33516, Egypt.
  • Locatelli M; Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
  • Pietrangelo T; Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
  • Tartaglia A; Department of Neuroscience Imaging and Clinical Sciences, Interuniversity Institute of Myology, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
  • Amoroso R; Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
  • Fulle S; Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
Molecules ; 25(23)2020 Dec 07.
Article en En | MEDLINE | ID: mdl-33297520
ABSTRACT
The increased risk of illness and disability is related to the age inevitable biological changes. Oxidative stress is a proposed mechanism for many age-related diseases. The crucial importance of polyphenol pharmacophore for aging process is largely described thanks to its effects on concentrations of reactive oxygen species. Resveratrol (3,5,4'-trihydroxy-trans-stilbene, RSV) plays a critical role in slowing the aging process but has a poor bioavailabity after oral intake. In this present work, a series of RSV derivatives was designed, synthesized, and evaluated as potential antioxidant agents. These derivatives contain substituents with different electronic and steric properties in different positions of aromatic rings. This kind of substituents affects the activity and the bioavailability of these compounds compared with RSV used as reference compound. Studies of Log P values demonstrated that the introduction of halogens gives the optimum lipophilicity to be considered promising active agents. Among them, compound 6 showed the higher antioxidant activity than RSV. The presence of trifluoromethyl group together with a chlorine atom increased the antioxidant activity compared to RSV.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Estilbenos / Técnicas de Química Sintética Límite: Animals / Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Estilbenos / Técnicas de Química Sintética Límite: Animals / Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Italia