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Synthesis of Sulfonamide-Based Ynamides and Ynamines in Water.
Zhao, Lei; Yang, Hongyi; Li, Ruikun; Tao, Ye; Guo, Xiao-Feng; Anderson, Edward A; Whiting, Andrew; Wu, Na.
Afiliación
  • Zhao L; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin, Guangxi 541004, China.
  • Yang H; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin, Guangxi 541004, China.
  • Li R; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin, Guangxi 541004, China.
  • Tao Y; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin, Guangxi 541004, China.
  • Guo XF; College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, Shanxi 030024, China.
  • Anderson EA; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K.
  • Whiting A; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.
  • Wu N; School of Chemistry and Bioscience, University of Bradford, Bradford, West Yorkshire BD7 1DP, U.K.
J Org Chem ; 86(2): 1938-1947, 2021 01 15.
Article en En | MEDLINE | ID: mdl-33356269
ABSTRACT
Ynamides, though relatively more stable than ynamines, are still moisture-sensitive and prone to hydration especially under acidic and heating conditions. Here we report an environmentally benign, robust protocol to synthesize sulfonamide-based ynamides and arylynamines via Sonogashira coupling reactions in water, using a readily available quaternary ammonium salt as the surfactant.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2021 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2021 Tipo del documento: Article País de afiliación: China