A practical guide to cancer subclonal reconstruction from DNA sequencing.
Nat Methods
; 18(2): 144-155, 2021 02.
Article
en En
| MEDLINE
| ID: mdl-33398189
ABSTRACT
Subclonal reconstruction from bulk tumor DNA sequencing has become a pillar of cancer evolution studies, providing insight into the clonality and relative ordering of mutations and mutational processes. We provide an outline of the complex computational approaches used for subclonal reconstruction from single and multiple tumor samples. We identify the underlying assumptions and uncertainties in each step and suggest best practices for analysis and quality assessment. This guide provides a pragmatic resource for the growing user community of subclonal reconstruction methods.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
ADN de Neoplasias
/
Análisis de Secuencia de ADN
/
Neoplasias
Tipo de estudio:
Guideline
Límite:
Humans
Idioma:
En
Revista:
Nat Methods
Asunto de la revista:
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Año:
2021
Tipo del documento:
Article
País de afiliación:
Reino Unido