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Volatile anaesthesia and peri-operative outcomes related to cancer: a feasibility and pilot study for a large randomised control trial.
Dubowitz, J A; Cata, J P; De Silva, A P; Braat, S; Shan, D; Yee, K; Hollande, F; Martin, O; Sloan, E K; Riedel, B.
Afiliación
  • Dubowitz JA; Department of Anaesthesia, Peri-operative and Pain Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia.
  • Cata JP; Department of Anesthesiology and Peri-operative Medicine, Division of Anesthesiology and Critical Care, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • De Silva AP; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, Australia.
  • Braat S; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, Australia.
  • Shan D; Department of Anaesthesia, Peri-operative and Pain Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia.
  • Yee K; Department of Anaesthesia, Peri-operative and Pain Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia.
  • Hollande F; Department of Clinical Pathology and University of Melbourne Centre for Cancer Research, Melbourne, Australia.
  • Martin O; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.
  • Sloan EK; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Australia.
  • Riedel B; Department of Anaesthesia, Peri-operative and Pain Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia.
Anaesthesia ; 76(9): 1198-1206, 2021 Sep.
Article en En | MEDLINE | ID: mdl-33440019
Published data suggest that the type of general anaesthesia used during surgical resection for cancer may impact on patient long-term outcome. However, robust prospective clinical evidence is essential to guide a change in clinical practice. We explored the feasibility of conducting a randomised controlled trial to investigate the impact of total intravenous anaesthesia with propofol vs. inhalational volatile anaesthesia on postoperative outcomes of patients undergoing major cancer surgery. We undertook a randomised, double-blind feasibility and pilot study of propofol total intravenous anaesthesia or volatile-based maintenance anaesthesia during cancer resection surgery at three tertiary hospitals in Australia and the USA. Patients were randomly allocated to receive propofol total intravenous anaesthesia or volatile-based maintenance anaesthesia. Primary outcomes for this study were successful recruitment to the study and successful delivery of the assigned anaesthetic treatment as per randomisation arm. Of the 217 eligible patients approached, 146 were recruited, a recruitment rate of 67.3% (95%CI 60.6-73.5%). One hundred and forty-five patients adhered to the randomised treatment arm, 99.3% (95%CI 96.2-100%). Intra-operative patient characteristics and postoperative complications were comparable between the two intervention groups. This feasibility and pilot study supports the viability of the protocol for a large, randomised controlled trial to investigate the effect of anaesthesia technique on postoperative cancer outcomes. The volatile anaesthesia and peri-operative outcomes related to cancer (VAPOR-C) study that is planned to follow this feasibility study is an international, multicentre trial with the aim of providing evidence-based guidelines for the anaesthetic management of patients undergoing major cancer surgery.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Complicaciones Posoperatorias / Anestesia por Inhalación / Anestesia Intravenosa / Neoplasias Tipo de estudio: Clinical_trials / Guideline Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte / Oceania Idioma: En Revista: Anaesthesia Año: 2021 Tipo del documento: Article País de afiliación: Australia

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Complicaciones Posoperatorias / Anestesia por Inhalación / Anestesia Intravenosa / Neoplasias Tipo de estudio: Clinical_trials / Guideline Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte / Oceania Idioma: En Revista: Anaesthesia Año: 2021 Tipo del documento: Article País de afiliación: Australia