Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination.

Nakamura, Kyosuke; Kustatscher, Georg; Alabert, Constance; Hödl, Martina; Forne, Ignasi; Völker-Albert, Moritz; Satpathy, Shankha; Beyer, Tracey E; Mailand, Niels; Choudhary, Chunaram; Imhof, Axel; Rappsilber, Juri; Groth, Anja

Nakamura, Kyosuke; Kustatscher, Georg; Alabert, Constance; Hödl, Martina; Forne, Ignasi; Völker-Albert, Moritz; Satpathy, Shankha; Beyer, Tracey E; Mailand, Niels; Choudhary, Chunaram; Imhof, Axel; Rappsilber, Juri; Groth, Anja.

Afiliación

Nakamura K; The Novo Nordisk Center for Protein Research (CPR), Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Kustatscher G; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, UK.
Alabert C; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Hödl M; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Forne I; Biomedical Center, Chromatin Proteomics Group, Department of Molecular Biology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Großhaderner Strasse 9, 82152 Planegg- Martinsried, Germany.
Völker-Albert M; Biomedical Center, Chromatin Proteomics Group, Department of Molecular Biology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Großhaderner Strasse 9, 82152 Planegg- Martinsried, Germany.
Satpathy S; The Novo Nordisk Center for Protein Research (CPR), Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Beyer TE; The Novo Nordisk Center for Protein Research (CPR), Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Mailand N; The Novo Nordisk Center for Protein Research (CPR), Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Choudhary C; The Novo Nordisk Center for Protein Research (CPR), Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Imhof A; Biomedical Center, Chromatin Proteomics Group, Department of Molecular Biology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Großhaderner Strasse 9, 82152 Planegg- Martinsried, Germany.
Rappsilber J; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, UK; Bioanalytics, Institute of Biotechnology, Technische Universität Berlin, 13355 Berlin, Germany. Electronic address: juri.rappsilber@tu-berlin.de.
Groth A; The Novo Nordisk Center for Protein Research (CPR), Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic addres

Mol Cell ; 81(5): 1084-1099.e6, 2021 03 04.

Article en En | MEDLINE | ID: mdl-33450211

Asunto(s)

Proteínas de la Ataxia Telangiectasia Mutada/genética; Proteínas de Ciclo Celular/genética; Replicación del ADN; ADN-Topoisomerasas de Tipo I/genética; ADN/genética; Proteínas Serina-Treonina Quinasas/genética; Proteínas Proto-Oncogénicas/genética; Reparación del ADN por Recombinación; Proteínas de la Ataxia Telangiectasia Mutada/antagonistas & inhibidores; Proteínas de la Ataxia Telangiectasia Mutada/metabolismo; Proteína BRCA1/genética; Proteína BRCA1/metabolismo; Camptotecina/farmacología; Proteínas de Ciclo Celular/metabolismo; Línea Celular Tumoral; Cromatina/química; Cromatina/metabolismo; ADN/metabolismo; Roturas del ADN de Doble Cadena; ADN-Topoisomerasas de Tipo I/metabolismo; Fibroblastos/citología; Fibroblastos/efectos de los fármacos; Fibroblastos/metabolismo; Puntos de Control de la Fase G1 del Ciclo Celular/efectos de los fármacos; Regulación de la Expresión Génica; Células HeLa; Humanos; Unión Proteica; Proteínas Serina-Treonina Quinasas/metabolismo; Proteómica/métodos; Proteínas Proto-Oncogénicas/metabolismo; Piridinas/farmacología; Quinolinas/farmacología; ARN Interferente Pequeño/genética; ARN Interferente Pequeño/metabolismo; Transducción de Señal; Inhibidores de Topoisomerasa I/farmacología; Ubiquitina-Proteína Ligasas/genética; Ubiquitina-Proteína Ligasas/metabolismo; Ubiquitinación/efectos de los fármacos; Quinasa Tipo Polo 1

Palabras clave

ATM; BRCA1-A; Camptothecin; NDRG3; NHEJ; PLK1; UBAP2; homologous recombination; nascent chromatin capture; replication stress

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: ADN / Proteínas Proto-Oncogénicas / Proteínas Serina-Treonina Quinasas / ADN-Topoisomerasas de Tipo I / Proteínas de Ciclo Celular / Replicación del ADN / Reparación del ADN por Recombinación / Proteínas de la Ataxia Telangiectasia Mutada Tipo de estudio: Prognostic_studies Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article País de afiliación: Dinamarca

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