Selective inhibition of acylpeptide hydrolase in SAOS-2 osteosarcoma cells: is this enzyme a viable anticancer target?

Gogliettino, Marta; Cocca, Ennio; Sandomenico, Annamaria; Gratino, Lorena; Iaccarino, Emanuela; Calvanese, Luisa; Rossi, Mosè; Palmieri, Gianna

Gogliettino, Marta; Cocca, Ennio; Sandomenico, Annamaria; Gratino, Lorena; Iaccarino, Emanuela; Calvanese, Luisa; Rossi, Mosè; Palmieri, Gianna.

Afiliación

Gogliettino M; Institute of Biosciences and BioResources, National Research Council (CNR-IBBR), 80131, Napoli, Italy.
Cocca E; Institute of Biosciences and BioResources, National Research Council (CNR-IBBR), 80131, Napoli, Italy.
Sandomenico A; Institute of Biostructure and Bioimaging, National Research Council (CNR-IBB), 80134, Napoli, Italy.
Gratino L; Institute of Biosciences and BioResources, National Research Council (CNR-IBBR), 80131, Napoli, Italy.
Iaccarino E; Institute of Biostructure and Bioimaging, National Research Council (CNR-IBB), 80134, Napoli, Italy.
Calvanese L; Institute of Biostructure and Bioimaging, National Research Council (CNR-IBB), 80134, Napoli, Italy.
Rossi M; Institute of Biosciences and BioResources, National Research Council (CNR-IBBR), 80131, Napoli, Italy.
Palmieri G; Institute of Biosciences and BioResources, National Research Council (CNR-IBBR), 80131, Napoli, Italy. gianna.palmieri@ibbr.cnr.it.

Mol Biol Rep ; 48(2): 1505-1519, 2021 Feb.

Article en En | MEDLINE | ID: mdl-33471263

Asunto(s)

Inhibidores Enzimáticos/química; Terapia Molecular Dirigida; Osteosarcoma/genética; Péptido Hidrolasas/genética; Apoptosis/genética; Línea Celular Tumoral; Proliferación Celular/genética; Supervivencia Celular/genética; Inhibidores Enzimáticos/uso terapéutico; Humanos; Osteosarcoma/tratamiento farmacológico; Osteosarcoma/patología; Péptido Hidrolasas/química; Péptido Hidrolasas/efectos de los fármacos; Complejo de la Endopetidasa Proteasomal/genética; Especificidad por Sustrato

Palabras clave

Acylpeptide hydrolase (APEH); Anti-cancer target; Enzyme inhibition; Osteosarcoma cell lines; Small molecule inhibitors

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Péptido Hidrolasas / Osteosarcoma / Inhibidores Enzimáticos / Terapia Molecular Dirigida Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Mol Biol Rep Año: 2021 Tipo del documento: Article País de afiliación: Italia

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