Design, synthesis, and biological evaluation of new urolithin amides as multitarget agents against Alzheimer's disease.

Shukur, Karar T; Ercetin, Tugba; Luise, Chiara; Sippl, Wolfgang; Sirkecioglu, Okan; Ulgen, Mert; Coskun, Goknil P; Yarim, Mine; Gazi, Mustafa; Gulcan, Hayrettin O

Shukur, Karar T; Ercetin, Tugba; Luise, Chiara; Sippl, Wolfgang; Sirkecioglu, Okan; Ulgen, Mert; Coskun, Goknil P; Yarim, Mine; Gazi, Mustafa; Gulcan, Hayrettin O.

Afiliación

Shukur KT; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, TR North Cyprus, Turkey.
Ercetin T; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, TR North Cyprus, Turkey.
Luise C; Institute of Pharmacy, Martin Luther University of Halle-Wittenberg, Halle (Saale), Germany.
Sippl W; Institute of Pharmacy, Martin Luther University of Halle-Wittenberg, Halle (Saale), Germany.
Sirkecioglu O; Department of Chemistry, Istanbul Technical University, Istanbul, Turkey.
Ulgen M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Acibadem University, Istanbul, Turkey.
Coskun GP; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Acibadem University, Istanbul, Turkey.
Yarim M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Yeditepe University, Istanbul, Turkey.
Gazi M; Faculty of Arts and Science, Eastern Mediterranean University, Famagusta, TR North Cyprus, Turkey.
Gulcan HO; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, TR North Cyprus, Turkey.

Arch Pharm (Weinheim) ; 354(5): e2000467, 2021 May.

Article en En | MEDLINE | ID: mdl-33511649

Asunto(s)

Enfermedad de Alzheimer/tratamiento farmacológico; Amidas/farmacología; Diseño de Fármacos; Inhibidores Enzimáticos/farmacología; Fármacos Neuroprotectores/farmacología; Acetilcolinesterasa/metabolismo; Enfermedad de Alzheimer/metabolismo; Amidas/síntesis química; Amidas/química; Butirilcolinesterasa/metabolismo; Relación Dosis-Respuesta a Droga; Inhibidores Enzimáticos/síntesis química; Inhibidores Enzimáticos/química; Humanos; Estructura Molecular; Monoaminooxidasa/metabolismo; Fármacos Neuroprotectores/síntesis química; Fármacos Neuroprotectores/química; Relación Estructura-Actividad

Palabras clave

Alzheimer's disease; MAO-B; amyloid beta; antioxidant; cholinesterase; urolithins

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Diseño de Fármacos / Fármacos Neuroprotectores / Inhibidores Enzimáticos / Enfermedad de Alzheimer / Amidas Límite: Humans Idioma: En Revista: Arch Pharm (Weinheim) Año: 2021 Tipo del documento: Article País de afiliación: Turquía

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