Syndecan-1 and stromal heparan sulfate proteoglycans: key moderators of plasma cell biology and myeloma pathogenesis.
Blood
; 137(13): 1713-1718, 2021 04 01.
Article
en En
| MEDLINE
| ID: mdl-33512430
ABSTRACT
Plasma cells no longer express a B-cell antigen receptor and are hence deprived of signals crucial for survival throughout B-cell development. Instead, normal plasma cells, as well as their malignant myeloma counterparts, heavily rely on communication with the bone marrow (BM) microenvironment for survival. The plasma cell heparan sulfate proteoglycan (HSPG) syndecan-1 (CD138) and HSPGs in the BM microenvironment act as master regulators of this communication by co-opting specific growth and survival factors from the BM niche. This designates syndecan-1/HSPGs and their synthesis machinery as potential treatment targets in multiple myeloma.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Células Plasmáticas
/
Proteoglicanos
/
Sindecano-1
/
Heparitina Sulfato
/
Mieloma Múltiple
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Blood
Año:
2021
Tipo del documento:
Article