Peripheral Inflammatory Cytokines and Lymphocyte Subset Features of Deceased COVID-19 Patients.
Biomed Res Int
; 2021: 9101082, 2021.
Article
en En
| MEDLINE
| ID: mdl-33542929
ABSTRACT
OBJECTIVE:
To compare the difference of inflammatory cytokines and lymphocyte subsets between deceased patients and survivors with COVID-19.METHODS:
This retrospective study included 254 confirmed patients from 10 January to 11 March, 2020, at Tongji Hospital of Wuhan, China. Laboratory and immunologic features were collected and analyzed, and the main outcomes focused on inflammatory cytokines and lymphocyte subsets.RESULTS:
A trend of markedly higher levels of inflammatory cytokines as well as lower lymphocyte subset levels in deceased patients was observed compared with survivors. ROC curve analyses indicated that inflammatory cytokines and the decrease levels of T cell, Th (helper T cells) cell, Ts (suppressor T cells) cell, B cell, and NK cell along with Th/Ts ratio increase could be used to predict the death of COVID-19. Multivariate analyses showed that higher levels of IL-6, IL-8, and IL-10 remained significantly correlated with shorter survival time and that the amount of Ts cells was negatively associated with the possibility of death in COVID-19 patients. In conclusion, SARS-CoV-2 would cause lymphopenia and result in decreased lymphocyte subset cells, particularly in Ts cell counts, which further induces hyperinflammatory response and cytokine storm. IL-6, IL-8, IL-10, and Ts cell might be independent predictors for the poor outcome of COVID-19.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Citocinas
/
Subgrupos Linfocitarios
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COVID-19
Tipo de estudio:
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
Biomed Res Int
Año:
2021
Tipo del documento:
Article
País de afiliación:
China