N-glycan-mediated shielding of ADAMTS13 prevents binding of pathogenic autoantibodies in immune-mediated TTP.

Ercig, Bogac; Graça, Nuno A G; Kangro, Kadri; Arfman, Tom; Wichapong, Kanin; Hrdinová, Johana; Kaijen, Paul; van Alphen, Floris P J; van den Biggelaar, Maartje; Vanhoorelbeke, Karen; Veyradier, Agnès; Coppo, Paul; Reutelingsperger, Chris; Nicolaes, Gerry A F; Männik, Andres; Voorberg, Jan

Ercig, Bogac; Graça, Nuno A G; Kangro, Kadri; Arfman, Tom; Wichapong, Kanin; Hrdinová, Johana; Kaijen, Paul; van Alphen, Floris P J; van den Biggelaar, Maartje; Vanhoorelbeke, Karen; Veyradier, Agnès; Coppo, Paul; Reutelingsperger, Chris; Nicolaes, Gerry A F; Männik, Andres; Voorberg, Jan.

Afiliación

Ercig B; Department of Molecular and Cellular Hemostasis, Sanquin-Academic Medical Center Landsteiner Laboratory, Amsterdam, The Netherlands.
Graça NAG; PharmaTarget BV, Maastricht, The Netherlands.
Kangro K; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
Arfman T; Department of Molecular and Cellular Hemostasis, Sanquin-Academic Medical Center Landsteiner Laboratory, Amsterdam, The Netherlands.
Wichapong K; Icosagen Cell Factory OÜ, Kambja vald, Tartumaa, Estonia.
Hrdinová J; Icosagen Cell Factory OÜ, Kambja vald, Tartumaa, Estonia.
Kaijen P; Laboratory for Thrombosis Research, IRF Life Sciences, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium.
van Alphen FPJ; Department of Molecular and Cellular Hemostasis, Sanquin-Academic Medical Center Landsteiner Laboratory, Amsterdam, The Netherlands.
van den Biggelaar M; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
Vanhoorelbeke K; Department of Molecular and Cellular Hemostasis, Sanquin-Academic Medical Center Landsteiner Laboratory, Amsterdam, The Netherlands.
Veyradier A; PharmaTarget BV, Maastricht, The Netherlands.
Coppo P; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
Reutelingsperger C; Department of Molecular and Cellular Hemostasis, Sanquin-Academic Medical Center Landsteiner Laboratory, Amsterdam, The Netherlands.
Nicolaes GAF; Research Facilities, Sanquin, Amsterdam, The Netherlands.
Männik A; Department of Molecular and Cellular Hemostasis, Sanquin-Academic Medical Center Landsteiner Laboratory, Amsterdam, The Netherlands.
Voorberg J; Laboratory for Thrombosis Research, IRF Life Sciences, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium.

Blood ; 137(19): 2694-2698, 2021 05 13.

Article en En | MEDLINE | ID: mdl-33544829

Asunto(s)

Proteína ADAMTS13/inmunología; Complejo Antígeno-Anticuerpo/química; Reacciones Antígeno-Anticuerpo; Autoanticuerpos/inmunología; Autoantígenos/inmunología; Polisacáridos/inmunología; Púrpura Trombocitopénica Trombótica/inmunología; Proteína ADAMTS13/química; Proteína ADAMTS13/metabolismo; Sustitución de Aminoácidos; Aminoácidos; Anticuerpos Monoclonales/inmunología; Complejo Antígeno-Anticuerpo/inmunología; Autoanticuerpos/metabolismo; Autoantígenos/química; Autoantígenos/metabolismo; Epítopos/inmunología; Epítopos/metabolismo; Humanos; Modelos Moleculares; Unión Proteica; Conformación Proteica; Dominios Proteicos; Factor de von Willebrand/metabolismo

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Polisacáridos / Púrpura Trombocitopénica Trombótica / Autoanticuerpos / Autoantígenos / Proteína ADAMTS13 / Complejo Antígeno-Anticuerpo / Reacciones Antígeno-Anticuerpo Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Blood Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos

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