Sex disparities and neutralizing antibody durability to SARS-CoV-2 infection in convalescent individuals.
medRxiv
; 2021 Feb 03.
Article
en En
| MEDLINE
| ID: mdl-33564775
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has now caused over 2 million deaths worldwide and continues to expand. Currently, much is unknown about functionally neutralizing human antibody responses and durability to SARS-CoV-2. Using convalescent sera collected from 101 COVID-19 recovered individuals 21-212 days after symptom onset with forty-eight additional longitudinal samples, we measured functionality and durability of serum antibodies. We also evaluated associations between individual demographic and clinical parameters with functional neutralizing antibody responses to COVID-19. We found robust antibody durability out to six months, as well as significant positive associations with the magnitude of the neutralizing antibody response and male sex. We also show that SARS-CoV-2 convalescent neutralizing antibodies are higher in individuals with cardio-metabolic comorbidities.
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Banco de datos:
MEDLINE
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En
Revista:
MedRxiv
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos