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Sex disparities and neutralizing antibody durability to SARS-CoV-2 infection in convalescent individuals.
Markmann, Alena J; Giallourou, Natasa; Bhowmik, D Ryan; Hou, Yixuan J; Lerner, Aaron; Martinez, David R; Premkumar, Lakshmanane; Root, Heather; van Duin, David; Napravnik, Sonia; Graham, Stephen D; Guerra, Quique; Raut, Rajendra; Petropoulos, Christos J; Wrin, Terri; Cornaby, Caleb; Schmitz, John; Kuruc, JoAnn; Weiss, Susan; Park, Yara; Baric, Ralph; de Silva, Aravinda M; Margolis, David M; Bartelt, Luther A.
Afiliación
  • Markmann AJ; Department of Medicine, Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill NC 27599, USA.
  • Giallourou N; Centre of Excellence in Biobanking and Biomedical Research, Molecular Medicine Research Center, University of Cyprus, Nicosia, Cyprus.
  • Bhowmik DR; Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill NC 27599, USA.
  • Hou YJ; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Lerner A; Department of Medicine, University of North Carolina School of Medicine, Chapel Hill NC 27599, USA.
  • Martinez DR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Premkumar L; Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill NC 27599, USA.
  • Root H; Department of Medicine, Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill NC 27599, USA.
  • van Duin D; Department of Medicine, Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill NC 27599, USA.
  • Napravnik S; Department of Medicine, Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill NC 27599, USA.
  • Graham SD; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Guerra Q; Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill NC 27599, USA.
  • Raut R; Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill NC 27599, USA.
  • Petropoulos CJ; Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill NC 27599, USA.
  • Wrin T; LabCorp-Monogram Biosciences, South San Francisco, CA 94080.
  • Cornaby C; LabCorp-Monogram Biosciences, South San Francisco, CA 94080.
  • Schmitz J; Department of Pathology & Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill NC 27599, USA.
  • Kuruc J; Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill NC 27599, USA.
  • Weiss S; Department of Pathology & Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill NC 27599, USA.
  • Park Y; Department of Medicine, Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill NC 27599, USA.
  • Baric R; UNC HIV Cure Center, University of North Carolina School of Medicine, Chapel Hill NC 27599, USA.
  • de Silva AM; Department of Pathology & Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill NC 27599, USA.
  • Margolis DM; Department of Pathology & Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill NC 27599, USA.
  • Bartelt LA; Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill NC 27599, USA.
medRxiv ; 2021 Feb 03.
Article en En | MEDLINE | ID: mdl-33564775
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has now caused over 2 million deaths worldwide and continues to expand. Currently, much is unknown about functionally neutralizing human antibody responses and durability to SARS-CoV-2. Using convalescent sera collected from 101 COVID-19 recovered individuals 21-212 days after symptom onset with forty-eight additional longitudinal samples, we measured functionality and durability of serum antibodies. We also evaluated associations between individual demographic and clinical parameters with functional neutralizing antibody responses to COVID-19. We found robust antibody durability out to six months, as well as significant positive associations with the magnitude of the neutralizing antibody response and male sex. We also show that SARS-CoV-2 convalescent neutralizing antibodies are higher in individuals with cardio-metabolic comorbidities.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: MedRxiv Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: MedRxiv Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos