[Phenotype- or genotype test for dihydropyrimidin dehydrogenase deficiency before treatment with a fluoropyrimidine].
Ugeskr Laeger
; 183(6)2021 02 08.
Article
en Da
| MEDLINE
| ID: mdl-33570023
Some patients may have partial or complete deficiency of dihydropyrimidin dehydrogenase (DPD) and be more likely to experience severe toxicity with 5-fluorouracil. Since the spring of 2020, the Danish Medicines Agency has recommended genotype or phenotype testing before treatment with a fluoropyrimidine, but the most appropriate test strategy is debated. In this review, we present polymorphisms in the genes coding for DPD and summarise the evidence for DPD-enzyme deficiency testing and pharmacokinetic guided dosing.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Deficiencia de Dihidropirimidina Deshidrogenasa
Límite:
Humans
Idioma:
Da
Revista:
Ugeskr Laeger
Año:
2021
Tipo del documento:
Article