Structural Insights into JAK2 Inhibition by Ruxolitinib, Fedratinib, and Derivatives Thereof.

Davis, Ryan R; Li, Baoli; Yun, Sang Y; Chan, Alice; Nareddy, Pradeep; Gunawan, Steven; Ayaz, Muhammad; Lawrence, Harshani R; Reuther, Gary W; Lawrence, Nicholas J; Schönbrunn, Ernst

Davis, Ryan R; Li, Baoli; Yun, Sang Y; Chan, Alice; Nareddy, Pradeep; Gunawan, Steven; Ayaz, Muhammad; Lawrence, Harshani R; Reuther, Gary W; Lawrence, Nicholas J; Schönbrunn, Ernst.

Afiliación

Davis RR; Drug Discovery DepartmentMoffitt Cancer Center, Tampa, Florida 33612, United States.
Li B; Drug Discovery DepartmentMoffitt Cancer Center, Tampa, Florida 33612, United States.
Yun SY; Chemical Biology Core, Moffitt Cancer Center, Tampa, Florida 33612, United States.
Chan A; Drug Discovery DepartmentMoffitt Cancer Center, Tampa, Florida 33612, United States.
Nareddy P; Drug Discovery DepartmentMoffitt Cancer Center, Tampa, Florida 33612, United States.
Gunawan S; Drug Discovery DepartmentMoffitt Cancer Center, Tampa, Florida 33612, United States.
Ayaz M; Chemical Biology Core, Moffitt Cancer Center, Tampa, Florida 33612, United States.
Lawrence HR; Chemical Biology Core, Moffitt Cancer Center, Tampa, Florida 33612, United States.
Reuther GW; Molecular Oncology Department, Moffitt Cancer Center, Tampa, Florida 33612, United States.
Lawrence NJ; Drug Discovery DepartmentMoffitt Cancer Center, Tampa, Florida 33612, United States.
Schönbrunn E; Drug Discovery DepartmentMoffitt Cancer Center, Tampa, Florida 33612, United States.

J Med Chem ; 64(4): 2228-2241, 2021 02 25.

Article en En | MEDLINE | ID: mdl-33570945

Asunto(s)

Janus Quinasa 2/antagonistas & inhibidores; Inhibidores de Proteínas Quinasas/farmacología; Pirazoles/farmacología; Pirrolidinas/farmacología; Sulfonamidas/farmacología; Línea Celular Tumoral; Cristalografía por Rayos X; Humanos; Janus Quinasa 2/metabolismo; Estructura Molecular; Nitrilos; Unión Proteica; Inhibidores de Proteínas Quinasas/química; Inhibidores de Proteínas Quinasas/metabolismo; Pirazoles/química; Pirazoles/metabolismo; Pirimidinas; Pirrolidinas/química; Pirrolidinas/metabolismo; Relación Estructura-Actividad; Sulfonamidas/química; Sulfonamidas/metabolismo

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirazoles / Pirrolidinas / Sulfonamidas / Inhibidores de Proteínas Quinasas / Janus Quinasa 2 Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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