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An evaluation of the diagnostic equivalence of 18F-FDG-PET between hybrid PET/MRI and PET/CT in drug-resistant epilepsy: A pilot study.
Poirier, Stefan E; Kwan, Benjamin Y M; Jurkiewicz, Michael T; Samargandy, Lina; Iacobelli, Maryssa; Steven, David A; Lam Shin Cheung, Victor; Moran, Gerald; Prato, Frank S; Thompson, R Terry; Burneo, Jorge G; Anazodo, Udunna C; Thiessen, Jonathan D.
Afiliación
  • Poirier SE; Lawson Imaging, Lawson Health Research Institute, London, ON, Canada; Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. Electronic address: spoirie6@uwo.ca.
  • Kwan BYM; Department of Diagnostic Radiology, Queen's University, Kingston, ON, Canada.
  • Jurkiewicz MT; Department of Medical Imaging, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
  • Samargandy L; Department of Medical Imaging, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
  • Iacobelli M; Lawson Imaging, Lawson Health Research Institute, London, ON, Canada.
  • Steven DA; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
  • Lam Shin Cheung V; Department of Medical Imaging, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
  • Moran G; Siemens Healthineers, Oakville, ON, Canada.
  • Prato FS; Lawson Imaging, Lawson Health Research Institute, London, ON, Canada; Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; Department of Medical Imaging, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
  • Thompson RT; Lawson Imaging, Lawson Health Research Institute, London, ON, Canada; Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; Department of Medical Imaging, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
  • Burneo JG; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
  • Anazodo UC; Lawson Imaging, Lawson Health Research Institute, London, ON, Canada; Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, Lond
  • Thiessen JD; Lawson Imaging, Lawson Health Research Institute, London, ON, Canada; Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; Department of Medical Imaging, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Epilepsy Res ; 172: 106583, 2021 05.
Article en En | MEDLINE | ID: mdl-33636504
ABSTRACT

OBJECTIVE:

Hybrid PET/MRI may improve detection of seizure-onset zone (SOZ) in drug-resistant epilepsy (DRE), however, concerns over PET bias from MRI-based attenuation correction (MRAC) have limited clinical adoption of PET/MRI. This study evaluated the diagnostic equivalency and potential clinical value of PET/MRI against PET/CT in DRE. MATERIALS AND

METHODS:

MRI, FDG-PET and CT images (n = 18) were acquired using a hybrid PET/MRI and a CT scanner. To assess diagnostic equivalency, PET was reconstructed using MRAC (RESOLUTE) and CT-based attenuation correction (CTAC) to generate PET/MRI and PET/CT images, respectively. PET/MRI and PET/CT images were compared qualitatively through visual assessment and quantitatively through regional standardized uptake value (SUV) and z-score assessment. Diagnostic accuracy and sensitivity of PET/MRI and PET/CT for SOZ detection were calculated through comparison to reference standards (clinical hypothesis and histopathology, respectively).

RESULTS:

Inter-reader agreement in visual assessment of PET/MRI and PET/CT images was 78 % and 81 %, respectively. PET/MRI and PET/CT were strongly correlated in mean SUV (r = 0.99, p < 0.001) and z-scores (r = 0.92, p < 0.001) across all brain regions. MRAC SUV bias was <5% in most brain regions except the inferior temporal gyrus, temporal pole, and cerebellum. Diagnostic accuracy and sensitivity were similar between PET/MRI and PET/CT (87 % vs. 85 % and 83 % vs. 83 %, respectively).

CONCLUSION:

We demonstrate here that PET/MRI with optimal MRAC can yield similar diagnostic performance as PET/CT. Nevertheless, further exploration of the potential added value of PET/MRI is necessary before clinical adoption of PET/MRI for epilepsy imaging.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas / Epilepsia / Epilepsia Refractaria Tipo de estudio: Diagnostic_studies / Guideline Límite: Humans Idioma: En Revista: Epilepsy Res Asunto de la revista: CEREBRO / NEUROLOGIA Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas / Epilepsia / Epilepsia Refractaria Tipo de estudio: Diagnostic_studies / Guideline Límite: Humans Idioma: En Revista: Epilepsy Res Asunto de la revista: CEREBRO / NEUROLOGIA Año: 2021 Tipo del documento: Article