Design, synthesis, and biological evaluation of 1,2,4-oxadiazole-containing pyrazolo[3,4-b]pyridinones as a new series of AMPKÉ1ß1Î³1 activators.

Xiao, Zhihong; Peng, Yajun; Zheng, Bifeng; Chang, Qi; Guo, Yating; Chen, Zhuo; Li, Qianbin; Hu, Gaoyun

Design, synthesis, and biological evaluation of 1,2,4-oxadiazole-containing pyrazolo[3,4-b]pyridinones as a new series of AMPKÉ1ß1Î³1 activators.

Xiao, Zhihong; Peng, Yajun; Zheng, Bifeng; Chang, Qi; Guo, Yating; Chen, Zhuo; Li, Qianbin; Hu, Gaoyun.

Afiliación

Xiao Z; Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
Peng Y; Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
Zheng B; Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
Chang Q; Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
Guo Y; Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
Chen Z; Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
Li Q; Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.
Hu G; Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.

Arch Pharm (Weinheim) ; 354(7): e2000458, 2021 Jul.

Article en En | MEDLINE | ID: mdl-33683726

Asunto(s)

Activadores de Enzimas/farmacología; Oxadiazoles/farmacología; Pirazoles/farmacología; Piridonas/farmacología; Proteínas Quinasas Activadas por AMP/efectos de los fármacos; Proteínas Quinasas Activadas por AMP/metabolismo; Animales; Apoptosis/efectos de los fármacos; Línea Celular; Diseño de Fármacos; Activación Enzimática/efectos de los fármacos; Activadores de Enzimas/síntesis química; Activadores de Enzimas/química; Fibroblastos/citología; Fibroblastos/efectos de los fármacos; Humanos; Riñón/citología; Riñón/efectos de los fármacos; Simulación del Acoplamiento Molecular; Oxadiazoles/síntesis química; Oxadiazoles/química; Pirazoles/síntesis química; Pirazoles/química; Piridonas/síntesis química; Piridonas/química; Ratas; Especies Reactivas de Oxígeno/metabolismo; Relación Estructura-Actividad

Palabras clave

AMPK; activator; apoptosis; pyrazolo[3,4-b]pyridinones; reactive oxygen species (ROS)

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxadiazoles / Pirazoles / Piridonas / Activadores de Enzimas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Arch Pharm (Weinheim) Año: 2021 Tipo del documento: Article País de afiliación: China

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