N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages.

Chen, Shuliang; Kumar, Sameer; Espada, Constanza E; Tirumuru, Nagaraja; Cahill, Michael P; Hu, Lulu; He, Chuan; Wu, Li

Chen, Shuliang; Kumar, Sameer; Espada, Constanza E; Tirumuru, Nagaraja; Cahill, Michael P; Hu, Lulu; He, Chuan; Wu, Li.

Afiliación

Chen S; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, United States of America.
Kumar S; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America.
Espada CE; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America.
Tirumuru N; Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, United States of America.
Cahill MP; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America.
Hu L; Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois, United States of America.
He C; Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois, United States of America.
Wu L; Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois, United States of America.

PLoS Pathog ; 17(3): e1009421, 2021 03.

Article en En | MEDLINE | ID: mdl-33690734

Asunto(s)

Infecciones por VIH/inmunología; VIH-1/metabolismo; Interferón Tipo I/biosíntesis; Células Mieloides/virología; Procesamiento Postranscripcional del ARN/inmunología; ARN Viral/metabolismo; Adenosina/análogos & derivados; Adenosina/metabolismo; Regulación de la Expresión Génica/inmunología; VIH-1/inmunología; Humanos; Inmunidad Innata/inmunología; Macrófagos/metabolismo; Macrófagos/virología; Monocitos/metabolismo; Monocitos/virología; Células Mieloides/inmunología; Células Mieloides/metabolismo; ARN Viral/inmunología

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: ARN Viral / Interferón Tipo I / Infecciones por VIH / Procesamiento Postranscripcional del ARN / VIH-1 / Células Mieloides Límite: Humans Idioma: En Revista: PLoS Pathog Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google