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Prognostic scoring models in parotid gland carcinoma.
Westergaard-Nielsen, Marie; Möller, Sören; Godballe, Christian; Grau Eriksen, Jesper; Larsen, Stine Rosenkilde; Kiss, Katalin; Agander, Tina; Parm Ulhøi, Benedicte; Charabi, Birgitte; Ehlers Klug, Tejs; Jacobsen, Henrik; Johansen, Jørgen; Kristensen, Claus Andrup; Andersen, Elo; Andersen, Maria; Bjørndal, Kristine.
Afiliación
  • Westergaard-Nielsen M; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark.
  • Möller S; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
  • Godballe C; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
  • Grau Eriksen J; OPEN - Open Patient data Explorative Network, Odense University Hospital, Odense, Denmark.
  • Larsen SR; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark.
  • Kiss K; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
  • Agander T; Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.
  • Parm Ulhøi B; Department of Pathology, Odense University Hospital, Odense, Denmark.
  • Charabi B; Department of Pathology, Rigshospitalet, Copenhagen, Denmark.
  • Ehlers Klug T; Department of Pathology, Rigshospitalet, Copenhagen, Denmark.
  • Jacobsen H; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark.
  • Johansen J; Department of Otorhinolaryngology, Head and Neck Surgery, Rigshospitalet, Copenhagen, Denmark.
  • Kristensen CA; Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Aarhus, Denmark.
  • Andersen E; Department of Otorhinolaryngology, Head and Neck Surgery, Aalborg University Hospital, Aalborg, Denmark.
  • Andersen M; Department of Oncology, Odense University Hospital, Odense, Denmark.
  • Bjørndal K; Department of Oncology, Rigshospitalet, Copenhagen, Denmark.
Head Neck ; 43(7): 2081-2090, 2021 07.
Article en En | MEDLINE | ID: mdl-33734517
ABSTRACT

BACKGROUND:

The aim was to identify prognostic factors and test three prognostic scoring models that predicted the risk of recurrence in patients with parotid gland carcinoma.

METHODS:

All Danish patients with parotid gland carcinoma, treated with curative intent, from 1990 to 2015 (n = 726) were included. Potential prognostic factors were evaluated using Cox regression and competing risk analyses. The concordance of each prognostic model was estimated using Harrel's C index.

RESULTS:

The study population consisted of 344 men and 382 women, with a median age of 63 years. Age above 60 years, high grade histology, T3/T4 tumor, regional lymph node metastases, and involved surgical margins were all associated with a significant reduction in recurrence-free survival. The prognostic model that agreed best with actual outcomes had a C-index of 0.76.

CONCLUSION:

Prognostic scoring models may improve individualized follow-up strategies after curatively intended treatment for patients with parotid gland carcinoma.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Parótida / Carcinoma Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Head Neck Asunto de la revista: NEOPLASIAS Año: 2021 Tipo del documento: Article País de afiliación: Dinamarca
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Parótida / Carcinoma Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Head Neck Asunto de la revista: NEOPLASIAS Año: 2021 Tipo del documento: Article País de afiliación: Dinamarca