[A case of dermatomyositis positive for anti-nuclear matrix protein 2 antibody without dermatologic symptoms].
Rinsho Shinkeigaku
; 61(4): 258-261, 2021 Apr 21.
Article
en Ja
| MEDLINE
| ID: mdl-33762494
ABSTRACT
We report a 47-year-old woman who presented with progressive myalgia, weakness in the proximal limbs, and dysphagia for a month and a half. No skin rash was observed on admission. Examination of MRI data suggested inflammatory changes in the proximal limbs and trunk muscles. Biopsy specimens from the left biceps muscle showed no perifascicular atrophy, but immunohistochemical staining revealed the presence of myxovirus resistance protein A (MxA) in myofibers, strongly suggesting dermatomyositis (DM). In addition, her serum was positive for anti-nuclear matrix protein 2 (anti-NXP-2) antibody, which is reportedly useful as a marker of DM without skin lesions. Her symptoms gradually improved upon intravenous methylprednisolone pulse therapy in conjunction with oral prednisolone, oral tacrolimus, and intravenous immunoglobulin therapy. Our findings suggest that in cases where inflammatory muscle disease is suspected, anti-NXP-2 antibody analyses should be considered for precise diagnosis, even if there are no dermatological symptoms.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Anticuerpos Antinucleares
/
Adenosina Trifosfatasas
/
Dermatomiositis
/
Proteínas de Unión al ADN
Tipo de estudio:
Diagnostic_studies
Límite:
Female
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Humans
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Middle aged
Idioma:
Ja
Revista:
Rinsho Shinkeigaku
Año:
2021
Tipo del documento:
Article