A human epidermal growth factor receptor 3/heregulin interaction inhibitor aptamer discovered using SELEX.

Yokoyama, Takumi; Ando, Takehiro; Iwamoto, Rina; Fuji, Daisuke; Yamamoto, Mizuki; Kawakami, Takashi

Yokoyama, Takumi; Ando, Takehiro; Iwamoto, Rina; Fuji, Daisuke; Yamamoto, Mizuki; Kawakami, Takashi.

Afiliación

Yokoyama T; Department of Life and Environmental Sciences, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, 4-4-37 Takeda, Kofu, Yamanashi, 400-8510, Japan.
Ando T; Department of Life and Environmental Sciences, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, 4-4-37 Takeda, Kofu, Yamanashi, 400-8510, Japan.
Iwamoto R; Department of Life and Environmental Sciences, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, 4-4-37 Takeda, Kofu, Yamanashi, 400-8510, Japan.
Fuji D; Department of Biotechnology, Faculty of Life and Environmental Sciences, University of Yamanashi, 4-4-37 Takeda, Kofu, Yamanashi, 400-8510, Japan.
Yamamoto M; Department of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, 4-4-37 Takeda, Kofu, Yamanashi, 400-8510, Japan.
Kawakami T; Faculty of Life and Environmental Sciences, Graduate Faculty of Interdisciplinary Research, University of Yamanashi, 4-4-37 Takeda, Kofu, Yamanashi, 400-8510, Japan; JST, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan. Electronic address: tkawakami@yamanashi.ac.jp.

Biochem Biophys Res Commun ; 553: 148-153, 2021 05 14.

Article en En | MEDLINE | ID: mdl-33770580

Asunto(s)

Aptámeros de Nucleótidos/análisis; Receptores ErbB/antagonistas & inhibidores; Neurregulina-1/antagonistas & inhibidores; Neurregulina-1/metabolismo; Receptor ErbB-3/antagonistas & inhibidores; Receptor ErbB-3/metabolismo; Técnica SELEX de Producción de Aptámeros; Aptámeros de Nucleótidos/aislamiento & purificación; Secuencia de Bases; Receptores ErbB/metabolismo; Humanos; Cinética; Luminiscencia; Unión Proteica/efectos de los fármacos; Receptor ErbB-3/química

Palabras clave

Aptamer; Cancer; HER3/HRG interaction Inhibitor; Heregulin; Human epidermal growth factor receptor 3; SELEX

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptor ErbB-3 / Neurregulina-1 / Aptámeros de Nucleótidos / Técnica SELEX de Producción de Aptámeros / Receptores ErbB Límite: Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2021 Tipo del documento: Article País de afiliación: Japón

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